Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Hydrogels based on N ‐isopropylacrylamide and 2‐hydroxyethylacrylate: synthesis, characterization and investigation of their antibacterial activity
View through CrossRef
Abstract
New thermosensitive hydrogels based on
N
‐isopropyl acrylamide and 2‐hydroxyethyl acrylate were prepared in the presence of ammonium persulfate as an initiator using a free‐radical technique. The thermal stability as well as the physical and chemical properties of the obtained hydrogel were studied by thermogravimetric analysis, differential scanning calorimetry and scanning electron microscopy. The swelling of the hydrogels was investigated by the cathetometer method. In order to use thermosensitive hydrogels as a carrier of antibiotics (lincomycin and gentamicin), several biological tests were performed. All samples of thermosensitive poly(
N
‐isopropyl acrylamide) and 2‐hydroxyethyl acrylate hydrogels containing medical substances exhibited antibacterial activity. The antibacterial activity of temperature‐sensitive hydrogels naturally increases with increasing concentration of antibiotics in the carrier. The results obtained indicate a large amount of drug was released from the hydrogels with full retention of antimicrobial properties. These copolymers can be used as an antibacterial material in the field of medicine. © 2020 Society of Chemical Industry
Title: Hydrogels based on
N
‐isopropylacrylamide and 2‐hydroxyethylacrylate: synthesis, characterization and investigation of their antibacterial activity
Description:
Abstract
New thermosensitive hydrogels based on
N
‐isopropyl acrylamide and 2‐hydroxyethyl acrylate were prepared in the presence of ammonium persulfate as an initiator using a free‐radical technique.
The thermal stability as well as the physical and chemical properties of the obtained hydrogel were studied by thermogravimetric analysis, differential scanning calorimetry and scanning electron microscopy.
The swelling of the hydrogels was investigated by the cathetometer method.
In order to use thermosensitive hydrogels as a carrier of antibiotics (lincomycin and gentamicin), several biological tests were performed.
All samples of thermosensitive poly(
N
‐isopropyl acrylamide) and 2‐hydroxyethyl acrylate hydrogels containing medical substances exhibited antibacterial activity.
The antibacterial activity of temperature‐sensitive hydrogels naturally increases with increasing concentration of antibiotics in the carrier.
The results obtained indicate a large amount of drug was released from the hydrogels with full retention of antimicrobial properties.
These copolymers can be used as an antibacterial material in the field of medicine.
© 2020 Society of Chemical Industry.
Related Results
Comparative Study of the Mechanical Properties of New PEGSSDA Hydrogels, and Their Effect on Embedded Stem Cell Secretome
Comparative Study of the Mechanical Properties of New PEGSSDA Hydrogels, and Their Effect on Embedded Stem Cell Secretome
Hydrogels are hyaluronic acid and collagen‐based polymer networks that mimic the 3D cell microenvironment and can be used as tissue‐engineered scaffolds for therapeutic delivery of...
Evaluating the Science to Inform the Physical Activity Guidelines for Americans Midcourse Report
Evaluating the Science to Inform the Physical Activity Guidelines for Americans Midcourse Report
Abstract
The Physical Activity Guidelines for Americans (Guidelines) advises older adults to be as active as possible. Yet, despite the well documented benefits of physical activi...
Investigating the Mesoscale of β-lactoglobulin Fibril Hydrogels
Investigating the Mesoscale of β-lactoglobulin Fibril Hydrogels
<p><b>The objective of this doctoral thesis was to investigate the relationship between the architecture of protein fibril networks and their macroscopic properties. Th...
Reinforcement of Injectable Hydrogel for Meniscus Tissue Engineering by Using Cellulose Nanofiber from Cassava Pulp
Reinforcement of Injectable Hydrogel for Meniscus Tissue Engineering by Using Cellulose Nanofiber from Cassava Pulp
Injectable hydrogels can be applied to treat damaged meniscus in minimally invasive conditions. Generally, injectable hydrogels can be prepared from various polymers such as polyca...
Inducing Microscale Structural Order in Phage Nanofilament Hydrogels via Macromolecular Crowding with Globular Proteins
Inducing Microscale Structural Order in Phage Nanofilament Hydrogels via Macromolecular Crowding with Globular Proteins
Biological hydrogels play important physiological roles in the body. These hydrogels often contain ordered subdomains that provide mechanical toughness and other tissue-specific fu...
ZnO-incorporated chitin hydrogels for infected wound therapy
ZnO-incorporated chitin hydrogels for infected wound therapy
Abstract
Chronic wounds caused by pathogenic bacterial infections have been a worldwide medical threat and challenge, ZnO is a promising antibacterial agent to promote infe...
Synthesis and characterization of n-isopropylacrylamide based copolymers with silver nanoparticles
Synthesis and characterization of n-isopropylacrylamide based copolymers with silver nanoparticles
In recent years, the so-called "smart" polymers, which can systematically respond to small environmental changes, such as pH, temperature and electric field, are widely used in man...
PEG-DA/Concanavalin A Biocomposite Hydrogels Synthesis And Investigations For Cancer Therapy
PEG-DA/Concanavalin A Biocomposite Hydrogels Synthesis And Investigations For Cancer Therapy
Drug therapy is an important research area in cancer treatment. Conconavalin a (ConA) is a lectin used for anti-cancer drug research because it can interact with cancer cells. In t...