A detailed review on some effects of turmeric curcuminoids on inflammation in obese individuals

Turmeric, derived from Curcuma longa, contains curcuminoids, notably curcumin, renowned for its anti-inflammatory and antioxidant properties. This review explores turmeric curcuminoids, focusing on curcumin, as potential remedies for obesity-related inflammation and associated disorders. The urgency to address obesity-related health risks is emphasized, with elevated BMI correlating with increased morbidity and mortality. Current obesity management strategies involve dietary changes, physical activity, and, sometimes, pharmacotherapy. Research suggests curcumin's role in significant weight loss and lean tissue mass augmentation, inhibiting adipogenesis-related proteins and increasing basal metabolic rate. The intricate connection between obesity and type 2 diabetes is examined, highlighting curcumin's impact on glucose homeostasis, hepatic gluconeogenesis, and lipid metabolism. Additionally, curcumin's anti-inflammatory effects, including modulation of pro-inflammatory cytokines and the NFkB pathway, demonstrate therapeutic potential. Clinical studies indicate curcumin's positive effects in reducing inflammatory markers and rebalancing adipokines in overweight and obese individuals, showing promise for addressing obesity-related inflammation and associated health risks. This review aims to investigate the potential role of turmeric curcuminoids, particularly curcumin, as remedies for obesity-related inflammation and associated disorders in obese individuals.