Validation of classical pharmacology of Sida cordifolia Linn. (Bala) through reverse pharmacology

Bala (Sida cordifolia Linn.) belonging to the Malvaceae family is one of the most frequently used herbs in Ayurveda therapeutics. It has been included in Agraya Prakarana (best among their class drugs) which signifies its role in various diseases. In Charaka Samhita, Bala has also been categorized under Balya, Brimhaniya and Prajasthapana Mahakashaya. It is used in several diseases like Vatavyadhi, Vatarakta and acts as a Rasayana. Ephedrine, pseudoephedrine, sterculic acid, malvalic acid are its main bioactive chemical constituents. It has been demonstrated to possess various pharmacological activities like CNS depressant, analgesic, anti-inflammatory, hypotensive, antidiabetic activities and the plant is reported to be used in the treatment of Parkinson’s disease also. In classical texts, five varieties of Bala have been mentioned and all are said to possess similar properties and actions. All the varieties are abundantly available across the country. Thus, Bala becomes one of the most potent medicinal plants of present era. Present paper is an attempt towards exploration of therapeutic potential of the drug through reverse pharmacology.