Manic switch during vortioxetine treatment: New medicine, new issue

Antidepressants have been linked to manic or hypomanic episodes in patient being treated for unipolar or bipolar depression. Knowledge of the risk of manic or hypomanic switch associated with a specific antidepressant assists clinicians in analyzing the risk-benefit ratio and finally prescribing an antidepressant of choice in a specific instance. Vortioxetine is now frequently utilized in clinical practice to treat unipolar depression. However, there is insufficient data on manic or hypomanic transition during vortioxetine treatment of unipolar depression. The purpose of this case report is to add to the existing literature on the vortioxetine-induced manic switch and the importance of considering risk factors before starting anti-depressants. Vortioxetine should be used with caution in patients with mood disorders.