Comparative analysis of the effectiveness of endoscopic methods of hemostasis in ulcerative gastroduodenal bleeding associated with the use of nonsteroidal anti-inflammatory drugs

The aim of the study: to conduct a comparative analysis of the effectiveness of endoscopic hemostasis methods for ulcerative gastroduodenal bleeding associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Materials and methods. We conducted a retrospective comparative analysis of the effectiveness of endoscopic hemostasis methods for bleeding ulcer (BU) associated with the use of NSAIDs in 97 patients in the period from 2023 to 2025. There were 56 men (57.7%), 41 women (42.3%). The average age of patients was 56.2 ± 6.4 years. Patients were divided into groups depending on the method of endoscopic hemostasis. The first group - 36 (37%) patients with injection method of endoscopic hemostasis (IEH). The second group - 32 (33%) patients with endoscopic argon plasma coagulation (APC). The third group - 29 (30%) patients with endoscopic clipping (EC). The groups of patients were comparable by gender and age. Statistical data processing was performed using the Statistica 10.0 program. Results. The groups did not differ in terms of hospitalization time, localization and size of the ulcer defect, as well as the severity of anemia. It was possible to successfully establish stable hemostasis, limited to one procedure, in 76 (78.4%) of 97 patients. The use of EC allowed achieving stable hemostasis in all patients during the first procedure, IEH was performed repeatedly in 8 (22.2%) of 36 patients, and APC - in 13 (40.6%) of 32.The number of deceased patients (5 (5.2%)) was not associated with the method of endoscopic hemostasis; the causes of death were multiple organ failure and severe anemia that could not be corrected. Conclusion. The adopted clinical guidelines for the prevention and treatment of esophago-gastro-entero-colopathy induced by NSAIDs, patient literacy and provision of hospitals providing care to patients with BU with effective methods of endoscopic hemostasis will help improve the treatment outcomes of patients with BU associated with NSAIDs.