Hyaluronic Acid Gel Effectiveness As An Adjunctive Treatment in Patients with Perio dontal Disease

Background: Both hard and soft periodontal components require hyaluronic acid (HA) for extracellular matrices to function properly. HA is crucial to understanding how inflammation and wound healing work. Different amounts of HA are found in periodontal tissues, including non-mineralized tissues like gingiva and periodontal ligament, and lesser levels in mineralized tissues like cementum and alveolar bone. Preliminary research indicates that HA can control periodontal tissue regeneration and treat periodontal disease. In both deeper periodontal tissues and marginal gingiva, HA helps to relieve symptoms. Aims: This research aimed to detect the influence of hyaluronic acid 1% gel as an adjunctive therapy on gingival crevicular fluid flow rate in patients with plaque-induced gingivitis. Materials and Methods: Throughout the study, fifty male patients with plaque-induced gingivitis were enrolled (25 per group) with a median age of 18 to 30 years old. They were split into two groups: Group 1 received scaling and treatment with chlorhexidine, and Group 2 received scaling and treatment with hyaluronic acid 0.1% gel. Patients were directed to use the hyaluronic acid gel to massage their gingiva twice daily for a week. Results: Gingival crevicular fluid (GCF) flow rate was measured using paper strips from four sampling tooth locations at baseline and day seven. The median GCF volume values at baseline showed no statistical difference between the two groups. However, the hyaluronic acid gel group exhibited a significantly reduced GCF volume at day seven post-treatment compared to baseline. The hyaluronic acid gel treatment significantly reduced GCF volume compared to the chlorhexidine group. Conclusion: The hyaluronic acid group was found to be significantly more effective in reducing GCF volume compared to the chlorhexidine group.