Lensless holographic trichoscopy and trichometry [for medical specialists]

A new principle of differential trichomorphological analysis and on-chip diagnostics is proposed. This principle can be considered as a transition from a trichoscope to a metrologically effective trichometer based on holographic laser, in particular, lensless holographic technology. In addition to obtaining an image in certain projections at different angles, this approach makes it possible to measure using orthogonal transformations, in particular, using the FFTW library based on software products such as QAVIS and KSA . With the help of the created technique, it is possible to register (and, with the accumulation of statistics, diagnose) such micromorphologically abnormal conditions as trichonodosis, trichoptilosis, trichonoresis, allotrichia, trichoclasia (including idiopathic trichoclasia), as well as some mesomorphological deviations (such as club-shaped, bayonet-shaped, loop-shaped, knotted hair). In addition, we simultaneously implement scanning of the profile of the features and relief of the underlying skin (for example, detection of nevi).The technology being created for non-damaging holographic micromorphological analysis can also be used in research practice, and not only for clinical diagnostics or preventive medicine. It is possible to combine schemes of lensless holographic on-chip trichometry with other methods of lensless on-chip microscopy, such as lensless interference microscopy, lensless incoherent holography on a chip and off-axis microholography on a chip, lensless polarizing microscopy and lensless differential interference contrast microscopy. The principles of expanding the pool of physical variables, parameters involved in the formation of an image as an analytical signal make it possible to obtain additional factors in the diagnosis biostatistics or additional descriptors in the database for identifying normal and "pathomorphological" states of an object.