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Data from EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance
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<div>Abstract<p>The lack of effective tumor-associated antigens restricts the development of targeted therapies against myeloid leukemia. In this study, we compared gene expression patterns of acute myeloid leukemia (AML) and normal bone marrow samples and found that epithelial cell adhesion molecule (EpCAM) is frequently overexpressed in patients with AML, with EpCAM<sup>+</sup> leukemic cells exhibiting enhanced chemoresistance and oncogenesis. The chemotherapeutic resistance of EpCAM-positive leukemic cells is a consequence of increased WNT5B signaling. Furthermore, we generated EpCAM antibodies that enabled phagocytosis or cytotoxicity of AML cells by macrophage or natural killer cells, respectively. Finally, EpCAM antibody treatment depleted AML in subcutaneous, disseminated, and intramedullary engrafted mice. In summary, EpCAM exhibits promise as a novel target for the treatment of leukemia. <i>Cancer Res; 77(2); 482–93. ©2016 AACR</i>.</p></div>
American Association for Cancer Research (AACR)
Title: Data from EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance
Description:
<div>Abstract<p>The lack of effective tumor-associated antigens restricts the development of targeted therapies against myeloid leukemia.
In this study, we compared gene expression patterns of acute myeloid leukemia (AML) and normal bone marrow samples and found that epithelial cell adhesion molecule (EpCAM) is frequently overexpressed in patients with AML, with EpCAM<sup>+</sup> leukemic cells exhibiting enhanced chemoresistance and oncogenesis.
The chemotherapeutic resistance of EpCAM-positive leukemic cells is a consequence of increased WNT5B signaling.
Furthermore, we generated EpCAM antibodies that enabled phagocytosis or cytotoxicity of AML cells by macrophage or natural killer cells, respectively.
Finally, EpCAM antibody treatment depleted AML in subcutaneous, disseminated, and intramedullary engrafted mice.
In summary, EpCAM exhibits promise as a novel target for the treatment of leukemia.
<i>Cancer Res; 77(2); 482–93.
©2016 AACR</i>.
</p></div>.
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Data from EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance
Data from EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance
<div>Abstract<p>The lack of effective tumor-associated antigens restricts the development of targeted therapies against myeloid leukemia. In this study, we compared gen...
Supplementary Figures from EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance
Supplementary Figures from EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance
<p>Supplementary Figure 1. Immunofluorescence and flow cytometry staining for EpCAM in leukemia and normal samples and leukemia cell lines. Supplementary Figure 2. Microarray...
Supplementary Figures from EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance
Supplementary Figures from EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance
<p>Supplementary Figure 1. Immunofluorescence and flow cytometry staining for EpCAM in leukemia and normal samples and leukemia cell lines. Supplementary Figure 2. Microarray...