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Endoglin Expression and Microvessel Density as Prognostic Factors in Pediatric Rhabdomyosarcoma
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(1) Background: The study proposed to analyze microvessel density (MVD) in rhabdomyosarcoma (RMS) based on the expression of angiogenesis markers and define its prognostic role in this group of patients. (2) Methods: The study included forty-nine pediatric patients diagnosed with RMS. Tumor tissue expression of CD31, CD34, and CD105 was analyzed. MVD was calculated and correlated with clinical RMS prognostic parameters. (3) Results: CD31, CD34, and CD105 are expressed in all RMS cases. MVD/CD105 was significantly higher in the RMS group than in the control group. The mean and median values of MVD/CD105 in RMS were lower than MVD/CD31 and MVD/CD34. MVD/CD105 was significantly higher in patients with alveolar RMS and those with metastatic disease. Patients with higher levels of MVD/CD105 had a higher risk of death (HR = 1.009). (4) Conclusion: CD105 is a relevant angiogenesis marker in pediatric RMS, and MVD/CD105 is an independent risk factor of short overall survival in children with RMS.
Title: Endoglin Expression and Microvessel Density as Prognostic Factors in Pediatric Rhabdomyosarcoma
Description:
(1) Background: The study proposed to analyze microvessel density (MVD) in rhabdomyosarcoma (RMS) based on the expression of angiogenesis markers and define its prognostic role in this group of patients.
(2) Methods: The study included forty-nine pediatric patients diagnosed with RMS.
Tumor tissue expression of CD31, CD34, and CD105 was analyzed.
MVD was calculated and correlated with clinical RMS prognostic parameters.
(3) Results: CD31, CD34, and CD105 are expressed in all RMS cases.
MVD/CD105 was significantly higher in the RMS group than in the control group.
The mean and median values of MVD/CD105 in RMS were lower than MVD/CD31 and MVD/CD34.
MVD/CD105 was significantly higher in patients with alveolar RMS and those with metastatic disease.
Patients with higher levels of MVD/CD105 had a higher risk of death (HR = 1.
009).
(4) Conclusion: CD105 is a relevant angiogenesis marker in pediatric RMS, and MVD/CD105 is an independent risk factor of short overall survival in children with RMS.
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