Perilla seed oil as an adjunctive treatment with a statin improves lipid profiles in elderly: a post hoc data analysis

Abstract Our previous study showed the potential benefit of perilla seed oil for improving lipid profiles in the elderly. We conducted a post hoc data analysis of our previous study to investigate the efficacy of perilla seed oil for improving lipid profiles in the elderly after the 6-month treatment. A total number of 182 patients with mild to moderate dementia were divided into four groups: a perilla seed oil and statins group (G1), a perilla seed oil group (G2), a statins group (G3), and the last group without perilla seed oil and statins (G4). The data were collected from Thammasat Hospital's electronic information system. Data on patients’ lipid levels and other laboratory results were collected before and after the 6-month treatment. Laboratory results were analyzed using One-way ANOVA and paired t-test analysis by SPSS software. The laboratory results after the treatment revealed that the mean values of total cholesterol, LDL-C, and LDL-C/HDL-C ratio from lipid profiles in G1, G2, and G3 decreased. In G1, total cholesterol decreased from 163.93 to 151.68 mg/dL (p-value = 0.00), and LDL-C decreased from 88.88 to 77.34 mg/dL, while the LDL-C/HDL-C ratio decreased from 1.73 to 0.24. In conclusion, the research showed that perilla seed oil decreased non-HDL cholesterols, especially LDL-C when combined with a statin. Therefore, perilla seed oil, in combination with a statin, enhances favorable lipid profiles.