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Distribution of CCR5-Δ32, CCR2-64I, and SDF1-3’A in Guangxi Zhuang Population
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Background: To investigate the distribution of CCR5-Δ32, CCR2-64I, and SDF1-3’A alleles in Guangxi province Zhuang population. Method: A total of 180 healthy individuals and 150 HIV-positive patients were recruited. All individuals were genotyped for CCR5 polymorphism using polymerase chain reaction (PCR), and CCR2 and SDF1 polymorphism using PCR restriction fragment length polymorphisms (PCR-RFLPs). Results: No CCR5-Δ32 mutation was found. CCR2-64I frequency was 24.7% in the healthy group and 20.3% in the HIV-positive group, and SDF1-3’A was 30.6% and 29.3% in the 2 groups, respectively. There were no significances in the frequencies of CCR2-64I (χ2 = 1.795, P = .180) and SDF1-3’A (χ2 = 0.116, P = .733) between the 2 groups. Conclusions: The protective CCR5-Δ32 mutation is absent in the Zhuang population, but CCR2-64I and SDF1-3’A are relatively common and seem not to confer protection against HIV-1 infection. The results suggest that the Zhuang people may have a similar genetic susceptibility to HIV-1 infection with most other Chinese ethnic groups.
Title: Distribution of CCR5-Δ32, CCR2-64I, and SDF1-3’A in Guangxi Zhuang Population
Description:
Background: To investigate the distribution of CCR5-Δ32, CCR2-64I, and SDF1-3’A alleles in Guangxi province Zhuang population.
Method: A total of 180 healthy individuals and 150 HIV-positive patients were recruited.
All individuals were genotyped for CCR5 polymorphism using polymerase chain reaction (PCR), and CCR2 and SDF1 polymorphism using PCR restriction fragment length polymorphisms (PCR-RFLPs).
Results: No CCR5-Δ32 mutation was found.
CCR2-64I frequency was 24.
7% in the healthy group and 20.
3% in the HIV-positive group, and SDF1-3’A was 30.
6% and 29.
3% in the 2 groups, respectively.
There were no significances in the frequencies of CCR2-64I (χ2 = 1.
795, P = .
180) and SDF1-3’A (χ2 = 0.
116, P = .
733) between the 2 groups.
Conclusions: The protective CCR5-Δ32 mutation is absent in the Zhuang population, but CCR2-64I and SDF1-3’A are relatively common and seem not to confer protection against HIV-1 infection.
The results suggest that the Zhuang people may have a similar genetic susceptibility to HIV-1 infection with most other Chinese ethnic groups.
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