Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Neuropharmacological characterization of insulin-sensitive CNS glucoregulator
View through CrossRef
Regional insulinization of the central nervous system (CNS) through the carotid artery causes an immediate decrease of the systemic blood sugar level in rats under light barbiturate anesthesia. Cervical vagotomy or intraperitoneal or intravenous atropine pretreatment results in partial inhibition of the systemic hypoglycemic response that follows intracarotid insulin injection. Intraperitoneal, intravenous, or intracarotid pretreatment with phentolamine or propranolol or intracarotid pretreatment with epinephrine had no effect on this centrally induced hypoglycemia. Intracarotid atropine injection immediately prior to intracarotid insulin injection completely abolished the systemic hypoglycemic response. Pretreatment with neostigmine administered intravenously prevented the inhibitory effect of intracarotid atropine on the hypoglycemic response that followed intracarotid insulin injection. It is consluded that the insulin-sensitive glucoregulator center of the CNS is under cholinergic influence, or its efferent pathways have a centrally located cholinergic synapsis.
Title: Neuropharmacological characterization of insulin-sensitive CNS glucoregulator
Description:
Regional insulinization of the central nervous system (CNS) through the carotid artery causes an immediate decrease of the systemic blood sugar level in rats under light barbiturate anesthesia.
Cervical vagotomy or intraperitoneal or intravenous atropine pretreatment results in partial inhibition of the systemic hypoglycemic response that follows intracarotid insulin injection.
Intraperitoneal, intravenous, or intracarotid pretreatment with phentolamine or propranolol or intracarotid pretreatment with epinephrine had no effect on this centrally induced hypoglycemia.
Intracarotid atropine injection immediately prior to intracarotid insulin injection completely abolished the systemic hypoglycemic response.
Pretreatment with neostigmine administered intravenously prevented the inhibitory effect of intracarotid atropine on the hypoglycemic response that followed intracarotid insulin injection.
It is consluded that the insulin-sensitive glucoregulator center of the CNS is under cholinergic influence, or its efferent pathways have a centrally located cholinergic synapsis.
Related Results
New and simple Ohmic definition of insulin resistance in lean and obese subjects
New and simple Ohmic definition of insulin resistance in lean and obese subjects
objective:: Insulin enhances the influx of glucose into cells. However, the relationship between glucose and insulin is complex and insulin sensitivity varies widely with age, ethn...
Pregnancy and Challenging Transient Anti-GAD65 Positivity: A Case Report with Literature Review
Pregnancy and Challenging Transient Anti-GAD65 Positivity: A Case Report with Literature Review
Abstract
Introduction
During pregnancy, women may develop blood glucose abnormalities like gestational diabetes mellitus (GDM) or, rarely, type 1 diabetes (T1D), which can lead to ...
Insulin Lispro: Its Role in the Treatment of Diabetes Mellitus
Insulin Lispro: Its Role in the Treatment of Diabetes Mellitus
OBJECTIVE:
To introduce a rapid-acting human insulin analog, insulin lispro; to review its pharmacology, therapeutics, pharmacokinetics, dosing guidelines, adve...
Mutations in Insulin-Receptor Gene in Insulin-Resistant Patients
Mutations in Insulin-Receptor Gene in Insulin-Resistant Patients
Defects in insulin-receptor function have been associated with insulin-resistant states such as obesity and non-insulin-dependent diabetes mellitus (NIDDM). Several types of mutati...
Effect of intranasal insulin on osteocalcin levels and postoperative delirium in elderly patients undergoing joint replacement
Effect of intranasal insulin on osteocalcin levels and postoperative delirium in elderly patients undergoing joint replacement
Abstract
Background
Recently, intranasal insulin has shown great promise in preventing perioperative neurocognitive disorders t...
Central nervous system
Central nervous system
Several different types of tumors, benign and malignant, have been identified in the central nervous system (CNS). The prognoses for these tumors are related to several factors, su...
A Case of Insulin Resistance Secondary to Insulin Induced Localized Cutaneous Amyloidosis.
A Case of Insulin Resistance Secondary to Insulin Induced Localized Cutaneous Amyloidosis.
Abstract
Abstract 4908
Insulin resistance can be a major problem in patients with diabetes mellitus. Although multiple reasons can result in this prob...
Partial Characterization of Mechanism of Insulin Accumulation in H35 Hepatoma Cell Nuclei
Partial Characterization of Mechanism of Insulin Accumulation in H35 Hepatoma Cell Nuclei
The mechanism controlling insulin accumulation in nuclei of H35 hepatoma cells was investigated by incubating intact cells with 125|-labeled insulin in the presence or absence of a...