EFFECTS OF ESMOLOL ON THE PREVENTION OF HEMODYNAMIC RESPONSE TO TRACHEAL INTUBATION

Introduction: Endotracheal extubation is almost always associated with haemodynamic changes. This increase in sympatho-adrenal activity may result in hypertension, tachycardia and arrhythmias and is more hazardous to the patients with hypertension, myocardial insufciency or cerebrovascular disease. Aims: To compare the effects of esmolol in attenuating the cardiovascular responses to tracheal extubation. Material And Method : After ethical committee's approval, this observational study was carried out on ASA class I-II patients. After pre-anaesthetic checkup, 60 patients were randomly allocated to 2 equal groups by using chit method. Patients were given 10 ml saline in Group – S, and 1mg/kg of esmolol diluted in 10 ml saline in Group – E. These drugs were given 3 minutes after reversal and 2 minutes before extubation. Statistical Analysis: The results were analyzed using ANOVA, student's paired t-test and chi-square test. 'p' value of <0.05 was statistically signicant and <0.001 was highly signicant. Results: Esmolol had greater attenuating effects on haemodynamic changes than control group. Attenuation on changes of heart rate and blood pressure was greater with esmolol Conclusion: esmolol 1mg/kg i.v. given at 2 min before extubation was of value in attenuating the cardiovascular changes during tracheal extubation & emergence from anaesthesia. Esmolol is more effective in attenuating the heart rate and systolic blood pressure