Biochemical parameters and oral fluid microcrystallization in young patients who use a vape device

The study aims s are researching the negative effect of nicotine-containing vapes on physical and chemical parameters of oral fluid and morphotyping of dried oral fluid drop among young somatically healthy individuals.  Material and methods. The study included 20 people between the ages of 18 and 24 years old, divided into 2 groups: the «Vape» group (n=12) human only nicotine-containing vape for at least 2 years and the «Control» group (n=8) not human nicotine in any form. pH, thiocyanate (rhodonide) concentrations, surface tension, oral fluid volume, hygiene indices and periodontal indices were studied. The morphotype of dried oral fluid drop was analyzed. Results. In the «Control» group in 3 cases gingivitis chronic K05.1 was diagnosed, and in the patients of the «Vape» group in 9 cases. It was found that the rhodonide content in the «Vape» group before «vaping» was higher than in the «Control» group and was Me= 1.31 mM/L and Me=0.58 mM/L respectively p=0.012. After vape application, the concentration of rhodonides in oral fluid increased in 1.16 times (p=0.0077), nitrite ions content from Me=0.09 mg/L to Me=0.32 mg/L (p=0.07), pH increased to Me=7.64; (LQ=7.45; HQ=7.67) (p=0.07) (p=0.07). The volume of RW in the Vape group remains 2.8 times smaller than in the Control group (p=0.012). The microcrystallization pattern of the oral fluid drop in the «Vape» group before «steaming» more often corresponded to type II A, and after «steaming» in 33.4% cases type III was determined, in 25% – type II B. Conclusions. Thus, in «vapers» of 18–24 years old statistically reliable reduction of oral fluid volume, high values of hygiene index shift of acid-base balance in the direction of alkalosis creates conditions in the oral cavity for the development of periodontal diseases and the emergence of cariesogenic situation. There was an increase in the concentration of rhodanide and nitrite ions, which in combination with other components of vape aerosols can be considered as procarcinogens, syncarcinogens and cocarcinogens. The change in the morphology of facies pattern, type of microcrystallization of oral fluid drop in the dynamics of vape use corresponds to the vector of changes observed in other inflammatory diseases of the oral cavity