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Identification of four novel HLA‐DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, by sequence‐based typing*
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Abstract: DOA sequences are currently known to have identical protein sequences. However, in this study, we report four novel allele types of human leucocyte antigen‐DOA, including one synonymous and three non‐ synonymous amino acid changes from the Korean population. DOA*010106 has identical protein sequence with previously known DOA*010103 except one nucleotide difference at codon 45 (TCG→TCA). In contrast, DOA*0102 and DOA*0103 have a sequence change at codon 99 (CTG→GTG) and codon 105 (CGC→TGC), causing non‐synonymous amino acid changes, Leu99Val and Arg105Cys, respectively. In addition, DOA*0104N has a sequence deletion at codon 36 (CCC→CC‐), resulting in a frame shift leading to a stop codon at codon 62.
Title: Identification of four novel HLA‐DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, by sequence‐based typing*
Description:
Abstract: DOA sequences are currently known to have identical protein sequences.
However, in this study, we report four novel allele types of human leucocyte antigen‐DOA, including one synonymous and three non‐ synonymous amino acid changes from the Korean population.
DOA*010106 has identical protein sequence with previously known DOA*010103 except one nucleotide difference at codon 45 (TCG→TCA).
In contrast, DOA*0102 and DOA*0103 have a sequence change at codon 99 (CTG→GTG) and codon 105 (CGC→TGC), causing non‐synonymous amino acid changes, Leu99Val and Arg105Cys, respectively.
In addition, DOA*0104N has a sequence deletion at codon 36 (CCC→CC‐), resulting in a frame shift leading to a stop codon at codon 62.
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