Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Nanobiotechnology-Enabled mRNA Stabilization
View through CrossRef
mRNA technology has attracted enormous interest due to its great therapeutic potential. Strategies that can stabilize fragile mRNA molecules are crucial for their widespread applications. There are numerous reviews on mRNA delivery, but few focus on the underlying causes of mRNA instability and how to tackle the instability issues. Herein, the recent progress in nanobiotechnology-enabled strategies for stabilizing mRNA and better delivery is reviewed. First, factors that destabilize mRNA are introduced. Second, nanobiotechnology-enabled strategies to stabilize mRNA molecules are reviewed, including molecular and nanotechnology approaches. The impact of formulation processing on mRNA stability and shelf-life, including freezing and lyophilization, are also briefly discussed. Lastly, our perspectives on challenges and future directions are presented. This review may provide useful guidelines for understanding the structure–function relationship and the rational design of nanobiotechnology for mRNA stability enhancement and mRNA technology development.
Title: Nanobiotechnology-Enabled mRNA Stabilization
Description:
mRNA technology has attracted enormous interest due to its great therapeutic potential.
Strategies that can stabilize fragile mRNA molecules are crucial for their widespread applications.
There are numerous reviews on mRNA delivery, but few focus on the underlying causes of mRNA instability and how to tackle the instability issues.
Herein, the recent progress in nanobiotechnology-enabled strategies for stabilizing mRNA and better delivery is reviewed.
First, factors that destabilize mRNA are introduced.
Second, nanobiotechnology-enabled strategies to stabilize mRNA molecules are reviewed, including molecular and nanotechnology approaches.
The impact of formulation processing on mRNA stability and shelf-life, including freezing and lyophilization, are also briefly discussed.
Lastly, our perspectives on challenges and future directions are presented.
This review may provide useful guidelines for understanding the structure–function relationship and the rational design of nanobiotechnology for mRNA stability enhancement and mRNA technology development.
Related Results
Tissue renin angiotensin system in IgA nephropathy
Tissue renin angiotensin system in IgA nephropathy
The inhibition of angiotensin II (AngII) by use of angiotensin converting enzyme (ACE) inhibitor or AngII receptor blocker is effective for prevention of the progression of renal d...
Impairment of HuR-Mediated FOS mRNA Stabilization in Granulocytes From Myelodysplastic Syndrome Patients.
Impairment of HuR-Mediated FOS mRNA Stabilization in Granulocytes From Myelodysplastic Syndrome Patients.
Abstract
Abstract 2805
Infection is a major cause of death in patients with myelodysplastic syndromes (MDS). Although qualitative and quantitative gra...
Long Versus Short-segment Stabilization in Patients with Traumatic Thoracolumbar Fractures
Long Versus Short-segment Stabilization in Patients with Traumatic Thoracolumbar Fractures
Background. Posterior stabilization surgery is considered the gold standard for restoring spine stability in patients with traumatic thoracolumbar fractures. However, whether long-...
Recent Advances in mRNA Vaccine Development
Recent Advances in mRNA Vaccine Development
Traditional vaccines are produced by using weakened or inactivated forms of disease-causing pathogens to produce the target antigen they are designed to protect against. Messenger ...
Design and Validation of Genes Encoding Hyperstable β-Globin mRNAs.
Design and Validation of Genes Encoding Hyperstable β-Globin mRNAs.
Abstract 4059
Poster Board III-994
Transgenic approaches to β thalassemia and sickle cell disease require viral vectors that express high levels of th...
Myocarditis and pericarditis in individuals exposed to the Ad26.COV2.S, BNT162b2 mRNA, or mRNA-1273 SARS-CoV-2 vaccines
Myocarditis and pericarditis in individuals exposed to the Ad26.COV2.S, BNT162b2 mRNA, or mRNA-1273 SARS-CoV-2 vaccines
ImportanceThere is a high level of public and professional interest related to potential safety issues of the COVID-19 vaccines; however, no serious adverse cardiovascular events w...
Abstract 3257: Unleashing immune power: How mRNA-encoded modulators suppress tumor growth
Abstract 3257: Unleashing immune power: How mRNA-encoded modulators suppress tumor growth
Abstract
Subsequent to the emergence of the COVID-19 pandemic, an increased number of nucleic acid-based therapeutics have secured clinical endorsement. Unlike conve...
Immune responses to mRNA vaccines : characteristics & the impact of host immune status
Immune responses to mRNA vaccines : characteristics & the impact of host immune status
<p dir="ltr">mRNA vaccines played a critical role in combating the SARS-CoV-2 pandemic and are progressing toward wider clinical use. However, much of how mRNA vaccines act u...