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Evaluation of Polyherbal Preparation Divya Medha Vati for Nootropic, Anxiolytic and Anticholinesterase Activity
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Divya Medha Vati is an Ayurvedic polyherbal preparation extensively used in the treatment of depression, stress, loss of memory both in children and adults. In the present study, aqueous solutions of dose (200 and 400 mg/kg, p.o) of Divya Medha Vati was evaluated for nootropic, antianxiety and anticholinesterase activity by using animal models. The dose dependent significant decrease in radial arm maze and Morris water maze performance was found in Divya Medha Vati treated group as compared to respective control group. Scopolamine and sodium nitrite was used for memory intoxication. The significant (p<0.001) increase in social interaction time was an indication of anxiolytic action in treated group. The dose dependent inhibitory action against haloperidol induced catalepsy and clonidine induced hypothermia was seen in Divya Medha Vati treated group. In addition, the treated group showed significant (p<0.001) decrease in level of anticholinesterase activity as compared with control group. Thus, polyherbal preparation Divya Medha Vati was proved potential remedy for cognition disorders.
BioMed Research Publishers
Title: Evaluation of Polyherbal Preparation Divya Medha Vati for Nootropic, Anxiolytic and Anticholinesterase Activity
Description:
Divya Medha Vati is an Ayurvedic polyherbal preparation extensively used in the treatment of depression, stress, loss of memory both in children and adults.
In the present study, aqueous solutions of dose (200 and 400 mg/kg, p.
o) of Divya Medha Vati was evaluated for nootropic, antianxiety and anticholinesterase activity by using animal models.
The dose dependent significant decrease in radial arm maze and Morris water maze performance was found in Divya Medha Vati treated group as compared to respective control group.
Scopolamine and sodium nitrite was used for memory intoxication.
The significant (p<0.
001) increase in social interaction time was an indication of anxiolytic action in treated group.
The dose dependent inhibitory action against haloperidol induced catalepsy and clonidine induced hypothermia was seen in Divya Medha Vati treated group.
In addition, the treated group showed significant (p<0.
001) decrease in level of anticholinesterase activity as compared with control group.
Thus, polyherbal preparation Divya Medha Vati was proved potential remedy for cognition disorders.
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