Design, Synthesis, Structural Characterization and Antimicrobial Screening of Several Novel Benzothiophene Linked Thiazolidines

A novel sequence of (19E)-(3-(benzo[b]thiophen-3-yl)-N′-((Z)-5-benzyliden-4-oxo-3-phenyl thiazolidin-2-ylidene)propanehydrazides (6a-f) was synthesized in moderate to good yields from the final intermediate, (E)-(3-(benzo[b]thiophen-3-yl)-N′-(4-oxo-3-phenylthiazolidin- 2-ylidene)propane hydrazide (5). In present work, 3-(benzo[b]thiophen-3-yl)propanoic acid (1) was selected as raw material and  compounds such as 1-(benzo[b]thiophen-3-yl)pentan-3-one (2), 3-(benzo[b]thiophen-3-yl)propanehydrazide (3) and 1-(3-(benzo[b]- thiophen-3-yl)-propanoyl)-4-phenylsemicarbazide (4) were materialized as intermediates. All the isolated intermediates and target  compounds have been characterized with the data obtained from different spectroscopic methods. The products were also examined  against few microorganisms. According to the screening results, the tested targets performed satisfactory growth of inhibition.