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Domino Oxidative Cyclization for the One‐Pot Synthesis of Pyrrolo[1, 2‐ a ]quinoxaline Derivatives
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Abstract
An oxidative cyclization of 1‐(2‐aminophenyl)pyrrole with styrenes has been developed for the synthesis of pyrrolo[1, 2‐
a
]quinoxaline derivatives using I
2
/2‐iodoxybenzoic acid (IBX) in DMSO as an effective oxidant. I
2
is found to catalyze effectively the oxidative cyclization of phenylacetylene and ethyl benzoylacetate with 1‐(2‐aminophenyl)pyrrole even in the absence of IBX to generate pyrrolo[1, 2‐
a
]quinoxaline derivatives under metal‐free conditions.
Title: Domino Oxidative Cyclization for the One‐Pot Synthesis of Pyrrolo[1, 2‐
a
]quinoxaline Derivatives
Description:
Abstract
An oxidative cyclization of 1‐(2‐aminophenyl)pyrrole with styrenes has been developed for the synthesis of pyrrolo[1, 2‐
a
]quinoxaline derivatives using I
2
/2‐iodoxybenzoic acid (IBX) in DMSO as an effective oxidant.
I
2
is found to catalyze effectively the oxidative cyclization of phenylacetylene and ethyl benzoylacetate with 1‐(2‐aminophenyl)pyrrole even in the absence of IBX to generate pyrrolo[1, 2‐
a
]quinoxaline derivatives under metal‐free conditions.
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