In Vivo Evaluation of Pithecellobium dulce Leaves Anti-bacterial and Antihyperlipidaemic Activities

AbstractThe natural origin and reduced side effects of medicinal plants have recently enhanced their popularity in both developed and developing nations.Pithecellobium dulce(P. dulce), an evergreen blooming spiky plant belonging to theFabaceaefamily, with a number of therapeutic uses.P. dulcehas medicinal qualities, such as antidiabetic, abortifacient, locomotor, anticonvulsant, antiulcer, and antioxidative ones. Unknown isP. dulce'sability to treat rats with hyperlipidaemia brought on by dexamethasone. In this article, we demonstrate how ethanolic leaf extract contains phytonutrients, has antibacterial action againstSalmonellaspecies, and has antihyperlipidemic activity against rats that have been given dexamethasone to cause hyperlipidaemia. Leaf extracts fromP. dulcecontain phytonutrients like phenols, flavonoids, and phytosterols. With increasing doses of the extract combined with the usual reference medicine atorvastatin, the levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and very low-density lipoprotein cholesterol were significantly decreased (VLDL-C). When compared to the antihyperlipidemic control, the extract was found to have dramatically enhanced HDL-C (70.78%), significantly decreased TC (47.03%), TG (47.51%), LDL-C (41.69%), and VLDL-C (48.00%). In contrast toEscherichia coli ATCC25922, which had the lowest inhibition zones, the 50mg/ml extract onSalmonella ATCC14028had the largest inhibition zone on all examined organisms.P. dulcehas demonstrated phytonutrients, antibacterial effectiveness, and antihyperlipidemic action in ethanolic leaf extract. Our research thus supports the use ofP. dulceas a potential candidate in the search for naturally occurring antibacterial and antihyperlipidemic chemicals.