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Inferring protein domain interactions from databases of interacting proteins

AbstractWe describe domain pair exclusion analysis (DPEA), a method for inferring domain interactions from databases of interacting proteins. DPEA features a log odds score, E ij , reflecting confidence that domains i and j interact. We analyzed 177,233 potential domain interactions underlying 26,032 protein interactions. In total, 3,005 high-confidence domain interactions were inferred, and were evaluated using known domain interactions in the Protein Data Bank. DPEA may prove useful in guiding experiment-based discovery of previously unrecognized domain interactions.

Springer Science and Business Media LLC

Robert Riley Christopher Lee Chiara Sabatti David Eisenberg

Genome Biology

2005

Title: Inferring protein domain interactions from databases of interacting proteins

Description:

AbstractWe describe domain pair exclusion analysis (DPEA), a method for inferring domain interactions from databases of interacting proteins.

DPEA features a log odds score, E ij , reflecting confidence that domains i and j interact.

We analyzed 177,233 potential domain interactions underlying 26,032 protein interactions.

In total, 3,005 high-confidence domain interactions were inferred, and were evaluated using known domain interactions in the Protein Data Bank.

DPEA may prove useful in guiding experiment-based discovery of previously unrecognized domain interactions.

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