(531) The Effect of Transdermal Testosterone Gel on Well-Being and Erectile Function in Hypogonadal Men

Abstract Introduction Well-being investigation have less been frequently examined in clinical research of testosterone replacement. The present study aimed to further determine the TRT effect of on mental well-being and erectile function in men with hypogonadism Objective The study aimed to evaluate the clinical effect on mental well-being and erectile function of transdermal testosterone gel after 6 months of administration Methods This multicenter, prospective study included men with hypogonadism treated with transdermal 1.62% testosterone gel for 6 months. The primary outcomes were World Health Organization (WHO)-5 Well-Being Index and treatment satisfaction, while secondary outcomes were International Index of Erectile Function scale-15 (IIEF-15) and waist circumference. Results A total of 114 participants underwent assessment. Hypogonadal men with a serum testosterone at baseline < 350 ng/dL (median: 259 ng/dL) had a significant improvement in testosterone level, with a median of 452 ng/dL after 6-month treatment. The mean WHO-5 Well-Being Index (Difference from baseline to 6th month: 0.6) and total IIEF-15 score (Difference from baseline to 6th month: 10) significantly increased after treatment (all p< 0.05). Men with a high baseline mean WHO-5 Well-Being Index (estimate [SE] =1.533 [0.107], p < 0.001) or high baseline total IIEF-15 score (estimate [SE] = 0.305 [0.110], p = 0.006) had a greater improvement in the change of WHO-5 Well-Being Index after 6-month transdermal testosterone therapy. It showed a significant correlation between the changes of mean IIEF-15 change and total WHO-5 Well-Being Index (r = 0.522, p < 0.001). Most men expressed satisfaction (scores ≥ 4) with overall health improvement (61.4%), improved mental vitality (62.3%), spontaneous erotic erection (49.1%), product drying time, skin irritation, smell and stickiness (58.8%), and product applied once daily (67.5%). The majority of adverse events were mild and included acne (12.3%), skin allergic reaction (5.3%), acute urinary retention (4.4%), and alopecia (1.8%). Conclusions In hypogonadal men, 1.62% transdermal testosterone gel has beneficial effects on improving well-being, and most men were satisfied with the treatment Disclosure No