Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Similar grey matter abnormalities in 22q11.2DS and chronic schizophrenia: a voxel-based morphometry study
View through CrossRef
Summary. Background. The 22q11.2 Deletion Syndrome (22q11.2DS) is considered the most reliable biological model to study genetic vulnerability to schizophrenia. It appears useful to investigate neuroanatomical characteristics of people with 22q11.2DS compared to chronic schizophrenia and healthy controls. Methods. The sample consisted of 16 individuals with a diagnosis of schizophrenia for over 10 years (SCZ>10), 14 with a diagnosis for less than 10 years (SCZ≤10), 11 patients with 22q11.2DS with no diagnosis of psychotic disorder (DEL, n=11) and 19 healthy controls (HCs, n=19). Global intelligence (IQ) was evaluated for all subjects. Voxel-Based Morphometry (VBM) was employed to investigate potential differences between groups in grey matter volumes. Results. VBM located the most significant difference between SCZ and HCs in the left medial frontal gyrus, where SCZ>10 group showed a significant reduction of grey matter volume; the same cluster resulted significantly decreased in DEL group compared to HCs as well. Despite the extensive grey matter abnormalities observed in 22q11.2DS, the DEL group showed the only significant differences compared to the SCZ>10 group in the right lingual gyrus volumes. Conclusions. Despite the small sample, our study identified a common area of grey matter loss both in idiopathic schizophrenia and 22q11.2DS.
Title: Similar grey matter abnormalities in 22q11.2DS and chronic schizophrenia: a voxel-based morphometry study
Description:
Summary.
Background.
The 22q11.
2 Deletion Syndrome (22q11.
2DS) is considered the most reliable biological model to study genetic vulnerability to schizophrenia.
It appears useful to investigate neuroanatomical characteristics of people with 22q11.
2DS compared to chronic schizophrenia and healthy controls.
Methods.
The sample consisted of 16 individuals with a diagnosis of schizophrenia for over 10 years (SCZ>10), 14 with a diagnosis for less than 10 years (SCZ≤10), 11 patients with 22q11.
2DS with no diagnosis of psychotic disorder (DEL, n=11) and 19 healthy controls (HCs, n=19).
Global intelligence (IQ) was evaluated for all subjects.
Voxel-Based Morphometry (VBM) was employed to investigate potential differences between groups in grey matter volumes.
Results.
VBM located the most significant difference between SCZ and HCs in the left medial frontal gyrus, where SCZ>10 group showed a significant reduction of grey matter volume; the same cluster resulted significantly decreased in DEL group compared to HCs as well.
Despite the extensive grey matter abnormalities observed in 22q11.
2DS, the DEL group showed the only significant differences compared to the SCZ>10 group in the right lingual gyrus volumes.
Conclusions.
Despite the small sample, our study identified a common area of grey matter loss both in idiopathic schizophrenia and 22q11.
2DS.
Related Results
Abnormal cortical activation during response inhibition in 22q11.2 deletion syndrome
Abnormal cortical activation during response inhibition in 22q11.2 deletion syndrome
Abstract22q11.2 deletion syndrome (22q11.2DS) is a well‐known genetic risk factor for schizophrenia. The catechol‐O‐methyltransferase (COMT) gene falls within the 22q11.2 minimal c...
Schizophrenia and 22q11.2 Deletion Syndrome
Schizophrenia and 22q11.2 Deletion Syndrome
Abstract
22q11.2 deletion syndrome (22q11.2DS), also known as velocardiofacial syndrome, is the most frequent known interstitial deletion found ...
22q11.2 Deletion Syndrome in Offspring Conceived via Assisted Reproductive Technology Versus Spontaneously
22q11.2 Deletion Syndrome in Offspring Conceived via Assisted Reproductive Technology Versus Spontaneously
Background/Objectives: The majority of chromosome 22q11.2 deletions are de novo, resulting from meiotic non-allelic homologous recombination (NAHR). While 22q11.2 deletion syndrome...
An Overview of the Trajectory of Brazilian Individuals with 22q11.2 Deletion Syndrome Until Diagnosis.
An Overview of the Trajectory of Brazilian Individuals with 22q11.2 Deletion Syndrome Until Diagnosis.
Abstract
Background: 22q11.2 Deletion Syndrome (22q11.2DS) is a rare disease that has as an important characteristic the clinical heterogeneity. The diversity of organs, re...
Myoclonic epilepsy, parkinsonism, schizophrenia and left-handedness as common neuropsychiatric features in 22q11.2 deletion syndrome
Myoclonic epilepsy, parkinsonism, schizophrenia and left-handedness as common neuropsychiatric features in 22q11.2 deletion syndrome
Background
22q11.2 deletion syndrome (22q11.2DS) is considered as the genetic model of schizophrenia. However, its polymorphic nature has led researchers to furth...
Everyday Life in the "Tourist Zone"
Everyday Life in the "Tourist Zone"
This article makes a case for the everyday while on tour and argues that the ability to continue with everyday routines and social relationships, while at the same time moving thro...
Novel 22q11.2 Deletions Detection Assay Using Gel Electrophoresis
Novel 22q11.2 Deletions Detection Assay Using Gel Electrophoresis
Background: 22q11.2 deletion syndrome (22q11.2DS), also known as Di-George/velocardiofacial syndrome is the most common chromosomal microdeletion and is frequently associated with ...
Analyses of thymocyte commitment to regulatory T cell lineage in thymus of healthy subjects and patients with 22q11.2 deletion syndrome
Analyses of thymocyte commitment to regulatory T cell lineage in thymus of healthy subjects and patients with 22q11.2 deletion syndrome
The Chromosome 22q11.2 deletion syndrome (22q11.2DS) results in an inborn error of immunity due to defective thymic organogenesis. Immunological abnormalities in 22q11.2DS patients...