Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Supramolecular Drug Delivery Systems Based on Host‐Guest Interactions for Nucleic Acid Delivery
View through CrossRef
AbstractIn bio‐medical field, one of the most challenging hurdles connected with development of therapeutics is the efficient transport and delivery of drugs to the infected cells of human body. Supramolecular chemistry provides innovative designs for effective biological applications such as drug and gene delivery. In various applications of supramolecular chemistry, macrocyclic molecules such as calixarenes, cyclodextrins, cucurbiturils, and pillar arenes serve as ideal hosts that can bind guest molecules based on the electron density and size of their cavities. This review focuses on the recent advancements in major supramolecular systems such as calixarenes (CA), curcurbiturils (CB), cyclodextrins (CD) and pillar[n] arenes (PAs). Owing to their non‐covalent interactions and adaptive capability, these supramolecular‐based nucleic acid delivery systems provide customized treatment options in cancer therapy. These supramolecular carriers are distinct due to their capacity to functionalize and alter their structure in accordance with the required application. The use of such amphiphilic macromolecules as a carrier for gene transfection have been thoroughly investigated leading to advancements in therapeutic research. The aim of this review is to highlight and showcase the endeavours of utilising supramolecular systems in drug/nucleic acid delivery.
Title: Supramolecular Drug Delivery Systems Based on Host‐Guest Interactions for Nucleic Acid Delivery
Description:
AbstractIn bio‐medical field, one of the most challenging hurdles connected with development of therapeutics is the efficient transport and delivery of drugs to the infected cells of human body.
Supramolecular chemistry provides innovative designs for effective biological applications such as drug and gene delivery.
In various applications of supramolecular chemistry, macrocyclic molecules such as calixarenes, cyclodextrins, cucurbiturils, and pillar arenes serve as ideal hosts that can bind guest molecules based on the electron density and size of their cavities.
This review focuses on the recent advancements in major supramolecular systems such as calixarenes (CA), curcurbiturils (CB), cyclodextrins (CD) and pillar[n] arenes (PAs).
Owing to their non‐covalent interactions and adaptive capability, these supramolecular‐based nucleic acid delivery systems provide customized treatment options in cancer therapy.
These supramolecular carriers are distinct due to their capacity to functionalize and alter their structure in accordance with the required application.
The use of such amphiphilic macromolecules as a carrier for gene transfection have been thoroughly investigated leading to advancements in therapeutic research.
The aim of this review is to highlight and showcase the endeavours of utilising supramolecular systems in drug/nucleic acid delivery.
Related Results
Introduction to supramolecular chemistry
Introduction to supramolecular chemistry
This chapter provides an overview of supramolecular chemistry, which broadly comprises of two main themes: host–guest chemistry and self-assembly. The control of intermolecular int...
Dysregulation in nucleic acid‐sensing pathway genes is associated with cancer patients’ prognosis
Dysregulation in nucleic acid‐sensing pathway genes is associated with cancer patients’ prognosis
AbstractThe innate immune system, the first line of defense against pathogens, is activated by nucleic acids from microbial invaders that are recognized by nucleic acid‐sensing rec...
The Promise of Exosomes as Drug Delivery Systems
The Promise of Exosomes as Drug Delivery Systems
Exosomes are small extracellular vesicles that play a role in cell-to-cell communication by transferring bioactive molecules such as proteins, nucleic acids, and lipids between cel...
Potential drug–drug interactions and associated factors among hospitalized cardiac patients at Jimma University Medical Center, Southwest Ethiopia
Potential drug–drug interactions and associated factors among hospitalized cardiac patients at Jimma University Medical Center, Southwest Ethiopia
Background: Concomitant use of several drugs for a patient is often imposing increased risk of drug–drug interactions. Drug–drug interactions are a major cause for concern in patie...
Supramolecular Polymerization with Dynamic Self-Sorting Sequence Control
Supramolecular Polymerization with Dynamic Self-Sorting Sequence Control
Synthetic polymerization and supramolecular polymerization with sequence control is far from an easy task. Herein, a narcissistic self-sorting supramolecular polymer is prepared wi...
Emergent RNA-RNA interactions can promote stability in a nascent phototrophic endosymbiosis
Emergent RNA-RNA interactions can promote stability in a nascent phototrophic endosymbiosis
ABSTRACTEukaryote-eukaryote endosymbiosis was responsible for the spread of chloroplast (plastid) organelles. Stability is required for the metabolic and genetic integration that d...
Applications of Supramolecular Polymers Generated from Pillar[n]arene-Based Molecules
Applications of Supramolecular Polymers Generated from Pillar[n]arene-Based Molecules
Supramolecular chemistry enables the manipulation of functional components on a molecular scale, facilitating a “bottom-up” approach to govern the sizes and structures of supramole...
Controlled Drug Delivery Systems
Controlled Drug Delivery Systems
In most forms of drug delivery, spatial localization and duration of drug concentration are constrained by organ physiology and metabolism. For example, drugs administered orally w...