RANDOMIZED CLINICAL TRIAL TO EVALUATE THE ROLE OF CHAKRAMAR-DA BEEJADI LEPA AND DURVADI LEPA IN THE MANAGEMENT OF DADRU

Introduction: Dadru Kushtha, described in Ayurvedic texts, is characterised by Udagata Mandala (raised patches), Kandu (itching), Raga (redness), and Pidika (eruptions). Based on clinical features, it can be correlated with fungal dermatophytosis in contemporary medicine. Conventional antifungal treatments often have side ef-fects and high recurrence rates, creating a need for safe and effective alternatives. This study aimed to evaluate and compare the efficacy of Chakramarda Beejadi Lepa and Durvadi Lepa administered with Panchatikta Ghrita in the management of Dadru Kushtha. Methods: A randomised clinical trial was conducted on patients diagnosed with Dadru Kushtha. Participants were divided into two groups: Group A received Panchatikta Ghri-ta with Chakramarda Beejadi Lepa, while Group B received Panchatikta Ghrita with Durvadi Lepa. The as-sessment was based on changes in clinical parameters, including Udagata Mandala, Kandu, Raga, Pidika, and Pruritus severity scale. Statistical analysis was applied to evaluate significance. Results: Both trial groups showed significant improvement in the clinical features of Dadru Kushtha. Group A demonstrated a higher aver-age percentage of relief (23.004%) compared to Group B (18.56%). The superior efficacy of Group A may be attributed to the Viparita Guna (opposite qualities) of Chakramarda Beejadi Lepa, which acts more effectively against the disease pathology. No adverse effects or abnormalities in renal and liver function tests were ob-served, confirming safety. Conclusion: The trial established that Panchatikta Ghrita with both Chakramarda Beejadi Lepa and Durvadi Lepa is effective and safe in the management of Dadru Kushtha. However, Chakramarda Beejadi Lepa exhibited slightly better efficacy, reaffirming the classical claims of its superiority in skin disorders. These findings support the clinical relevance of Ayurvedic formulations as promising alternatives to conventional antifungal therapy.