GW24-e0760 Effects of rosuvastatin on rats with dyslipidemia and antiatherosclerotic

Objectives To explore the regulating lipid effects of Rosuvastatin on rats with dyslipidemia and its antiatherosclerotic effects. Methods Thirty-six male SD rats were randomly divided into normal group raised with normal feed, hyperlipidemia control group fed with high fat and Rosuvastatin treating group also fed with high fat. Blood TC, TG, LDL-C, HDL-C, CRP, IL-6, ox-LDL, ALT and Cr were examined before and after intervention. Artery specimens were dissected for pathological evaluation on atherosclerosis. Data and statistics were dealt with Excel and the statistics software SPSS 13.0. Statistically significant difference was defined as P < 0.05. Results 1) Rosuvastatin could markedly decrease the levels of TC and low LDL-C. 2) The levels of CRP, IL-6 and ox-LDL were significantly reduced only in Rosuvastatin treating groups after intervention. 3) No obvious hepatic and renal adverse reaction were found in the Rosuvastatin treating group after intervention. 4) Atherosclerotic lesions were diffuse and severe in hyperlipidemia control group, but no typical atherosclerotic lesions were found in Rosuvastatin treating group. Conclusions 1) Rosuvastatin could effectively and safely regulate lipid; 2) Rosuvastatin could prevent atherosclerosis by inhibiting inflammatory reaction via lowering CRP and IL-6 and by protecting endothelial function of blood vessels via lowering ox-LDL.