Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Histopathologic Study of Cholestasis Induced by Total Parenteral Nutrition or Intraperitoneal Sepsis in Rats
View through CrossRef
Wistar rats were divided into two groups, intraperitoneal sepsis group (group IS) and total parenteral nutrition group (group TPN), to evaluate the characteristics of pathologic alterations in rats with cholestasis. Biochemical assay showed that cholestasis developed in both groups after 10 days. Light microscopic examination of liver specimens revealed that the degeneration in the intermediate and external zone of hepatolobules was the major alteration in group IS, and group TPN showed characteristic dilation of central veins and hepatic sinuses and the proliferation of Kupffer cells with marked phagocytosis. Electron microscopic pictures presented the enlargement of bile canaliculi with altered microvilli in group IS and many highly electron‐dense bile particles within cytoplasm and secondary lysosomes near dilated bile canaliculi in group TPN. It is concluded that there were different histopathologic alterations of liver specimens in TPN‐supported animals and septic animals when cholestasis developed. It is unsuitable to take intraperitoneal sepsis as a unique factor of cholestasis in TPN‐supported rats. Bile stasis is only one sign of TPN‐induced hepatic lesion, which needs further exploration to determine its causes and mechanisms. (Journal of Parenteral and Enteral Nutrition 15:630–636, 1991)
Title: Histopathologic Study of Cholestasis Induced by Total Parenteral Nutrition or Intraperitoneal Sepsis in Rats
Description:
Wistar rats were divided into two groups, intraperitoneal sepsis group (group IS) and total parenteral nutrition group (group TPN), to evaluate the characteristics of pathologic alterations in rats with cholestasis.
Biochemical assay showed that cholestasis developed in both groups after 10 days.
Light microscopic examination of liver specimens revealed that the degeneration in the intermediate and external zone of hepatolobules was the major alteration in group IS, and group TPN showed characteristic dilation of central veins and hepatic sinuses and the proliferation of Kupffer cells with marked phagocytosis.
Electron microscopic pictures presented the enlargement of bile canaliculi with altered microvilli in group IS and many highly electron‐dense bile particles within cytoplasm and secondary lysosomes near dilated bile canaliculi in group TPN.
It is concluded that there were different histopathologic alterations of liver specimens in TPN‐supported animals and septic animals when cholestasis developed.
It is unsuitable to take intraperitoneal sepsis as a unique factor of cholestasis in TPN‐supported rats.
Bile stasis is only one sign of TPN‐induced hepatic lesion, which needs further exploration to determine its causes and mechanisms.
(Journal of Parenteral and Enteral Nutrition 15:630–636, 1991).
Related Results
To Determine The Association Of Serum Neopterin Levels In Sepsis
To Determine The Association Of Serum Neopterin Levels In Sepsis
Abstract
ABSTRACT
Background: Sepsis is a leading cause of death worldwide. Sepsis results in state of multiorgan dysfunction in the body. Early identification and appropri...
Sepsis-Related Mortality Rates and Trends Based on Site of Infection
Sepsis-Related Mortality Rates and Trends Based on Site of Infection
OBJECTIVES:
Sepsis is defined as life-threatening organ dysfunction triggered by an underlying infection. A recent study noted that the overall sepsis-related mortality...
Parenteral Nutrition-Induced Cholestasis in Neonates: Where Does the Problem Lie?
Parenteral Nutrition-Induced Cholestasis in Neonates: Where Does the Problem Lie?
Background. Parenteral nutrition (PN) is an effective method of nourishing the neonate who is unable to receive full enteral feeds. Cholestasis can be a complication of PN and can ...
Parenteral nutrition in the critically ill
Parenteral nutrition in the critically ill
Purpose of review
Feeding guidelines have recommended early, full nutritional support in critically ill patients to prevent hypercatabolism and muscle weakness. Early e...
Matrix metalloproteinase-8 inhibitors mitigate sepsis-induced myocardial injury in rats
Matrix metalloproteinase-8 inhibitors mitigate sepsis-induced myocardial injury in rats
BackgroundSepsis-induced myocardial injury (SIMI) is caused by a variety of mechanisms. The aim of the study is to investigate the effects of metalloproteinase-8 (MMP-8) on SIMI an...
Enteral and Parenteral Nutrition
Enteral and Parenteral Nutrition
Alternative routes of nutrient administration are available for patients who are unable to eat or digest sufficient food to prevent malnutrition. These routes include enteral (admi...
Infusion therapy for sepsis in patients with burns
Infusion therapy for sepsis in patients with burns
Background. Sepsis develops in 8-42.5 % of patients with burns and is the leading cause of death among them. The criteria for sepsis are suspected or documented infection and the p...
Ursodeoxycholic acid in neonatal sepsis-associated cholestasis
Ursodeoxycholic acid in neonatal sepsis-associated cholestasis
Background Sepsis-associated cholestasis (SAC) is an intrahepatic cholestasis caused by inflammatory cytokines. Patients with this condition have poor prognoses. Antibiotics are th...