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Supplementary Figures S1 - S8 from Bayesian Modeling Identifies PLAG1 as a Key Regulator of Proliferation and Survival in Rhabdomyosarcoma Cells
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<p>S1. Confirmation of knockdown of PLAG1 in RMS cells. S2. Knockdown of PLAG1 increases cleaved PARP1 expression in RD-like cells. S3. Knockdown of PLAG1 with another siRNA (#2) also impairs cell accumulation and induces apoptosis in RMS cells. S4. Knockdown of PLAG1 decreases IGF2 expression in RH30 cells. S5. Exogenous IGF2 decreases the sub-G1 cell population triggered by PLAG1 knockdown. S6. Addition of IGF2 partially restores attenuated AKT phosphorylation induced by PLAG1 knockdown in RH30 cells. S7. Ectopic expression of PLAG1 induces IGF2 and activates IGF1R in RH30 cells. S8. BMS754807 inhibits IGF1R phosphorylation in RD cells.</p>
American Association for Cancer Research (AACR)
Title: Supplementary Figures S1 - S8 from Bayesian Modeling Identifies PLAG1 as a Key Regulator of Proliferation and Survival in Rhabdomyosarcoma Cells
Description:
<p>S1.
Confirmation of knockdown of PLAG1 in RMS cells.
S2.
Knockdown of PLAG1 increases cleaved PARP1 expression in RD-like cells.
S3.
Knockdown of PLAG1 with another siRNA (#2) also impairs cell accumulation and induces apoptosis in RMS cells.
S4.
Knockdown of PLAG1 decreases IGF2 expression in RH30 cells.
S5.
Exogenous IGF2 decreases the sub-G1 cell population triggered by PLAG1 knockdown.
S6.
Addition of IGF2 partially restores attenuated AKT phosphorylation induced by PLAG1 knockdown in RH30 cells.
S7.
Ectopic expression of PLAG1 induces IGF2 and activates IGF1R in RH30 cells.
S8.
BMS754807 inhibits IGF1R phosphorylation in RD cells.
</p>.
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