Evaluation of varying doses of ethanol leave extract of senna occidentalis, annona muricata and aju-mbaise on liver biochemical parameters and hematological indices in Wistar rats

Purpose of the Research: This research evaluated the effect of varying doses of ethanol extract leaves of Senna occidentalis, Annona muricata, and Aju-mbaise on the liver biochemical parameters and hematological indices in Wistar rats. Scope of the experiment: Twenty Wistar rats weighing 120 g to 150 g were used. They were distributed into four groups, with five rats each. Group one served as a control and was given water and normal rat chow. Groups 2, 3, and 4 were given S. occidentalis, A. muricata, and A. mbaise extracts for 30 days, respectively. At the end of the experiment, blood samples were collected for hematological and biochemical analysis. Liver tissue was also harvested for histopathological examination. Result: There was a significant increase (p < 0.05) in the hematological parameters of rats that were administered A. muricata and A. mbaise. For the liver enzymes (ALT, AST, and ALP), there was no significant (p < 0.05) increase across the test groups when compared with the control. However, A. mbaise administration resulted in alterations in serum concentration of conjugated bilirubin and serum albumin when compared with other test groups and with the control. Histological examination of the liver tissue revealed that the extract of A. muricata resulted in liver toxicity. Conclusion: The result implies that A. mbaise may lead to hemolysis, which can result in anemia as opposed to S. occidentalis and A. muricata, while A. muricata can result in liver toxicity.