Neurofibroma on the tongue: a rare case report

Neurofibromas are sporadic or associated with type 1 neurofibromatosis (NF1), with a higher risk of malignant progression. Oral Neurofibromas are peripheral nerve sheath tumors, similar to Schwannomas. Solitary neurofibroma is a rare benign non-odontogenic tumor. Particularly in the oral cavity, neurogenic tumors are rare, especially if they are malignant. Neurofibromas may present either as solitary lesions or as part of the generalized syndrome of neurofibromatosis or von Recklinghausen's disease of the skin. Clinically, oral Neurofibromas usually appear as pedunculated or sessile nodules, with slow growth and mostly without pain. The diagnosis can be confirmed by histological examination. Histological variations in oral neurofibromas are relatively uncommon. Neurofibromas are immunopositive for the S-100 protein, indicating its neural origin. Treatment is surgical and the prognosis is excellent.