Journal of Pharmaceutical Negative Results ¦ Volume 13 ¦ Special Issue 9 ¦ 2022 1734 PHOSPHATE BINDERS AS A SUPPLEMENT-ASSESSMENT OF KNOWLEDGE, ATTITUDE AND PRACTICE AMONG ESRD PATIENTS ON MAINTENANCE HEMODIALYSIS IN A TERTIARY CARE TEACHING HOSPITAL IN S

Objectives: To assess the Knowledge, Attitude and Practice regarding phosphate binders among ESRD patients on maintenance hemodialysis in South India. And also, to assess its adverse effects and the impact on the gastrointestinal system. Methods: We conducted a cross sectional prospective study at nephroplus and vakula dialysis center in SVIMS, Tirupati for a period of 6 months. A total 226 patients were included in the study, who are on hemodialysis between November 2021 to April 2022. The study involved interviewing the patients, reviewing their medical records to assess the patients Knowledge, Attitude, Practice regarding these phosphate binders and to understand the impact of these binders on the GI system. Results: We included 226 patients in our study. 73:27 was the male and female ratio. The prevalence of prescribing calcium phosphate binders was 37%, non-calcium phosphate binders was 14% and combination of both binders was 49%. Most patients showed adequate to good attitudes towards phosphate balance. Calcium based phosphate binders had more effect on GI system when compared to the patients using non-calcium-based phosphate binders. Conclusion: Patients receiving hemodialysis mostly use phosphate binders. Binders negative impact on GI system is more due to low awareness level. Additionally, they claimed that nutrition restrictions during dialysis were not implemented with sufficient care and had poor compliance procedures. Further, we recommend efficacious patient counseling programs need to carried out to improve the awareness and knowledge of these phosphate binders among hemodialysis patients to minimize adverse effects.