Passiflora as A Natural Remedy for Alzheimer’s disease: Current Evidences

Alzheimer’s disease is a progressive, globally prevalent neurodegenerative disorder characterized by cognitive decline, memory impairment, and hallmark pathological features such as extracellular amyloid-beta plaques and intracellular neurofibrillary tangles composed of hyperphosphorylated tau protein. This review discusses the neuroprotective potential of Passiflora species has attracted growing scientific attention with a longstanding history of use for their sedative, anxiolytic, and anti-inflammatory properties. Preclinical studies have shown that extracts from Passiflora incarnata and Passiflora edulis possess multifaceted benefits in experimental models of Alzheimer’s disease, including attenuation of amyloid-beta-induced neurotoxicity, inhibition of tau protein hyperphosphorylation, and enhanced cognitive performance. The bioactive constituents attributed to these effects primarily flavonoids, alkaloids, and phenolic acids are noted for their potent antioxidant and anti-inflammatory activities. The extensive traditional use of Passiflora, combined with its diverse pharmacological actions and favorable safety profile, positions it as a promising candidate for adjunctive therapy in Alzheimer’s disease. Further investigation into Passiflora and its active compounds may provide valuable opportunities for the development of disease-modifying interventions for Alzheimer’s and related neurodegenerative disorders.