Association Between Zinc Level and Prelabour Rupture of Membranes

Background: Assessment of micronutrients in pregnant women particularly ZINC and whether its concentration is different between term and preterm birth is important to optimize the normal pregnancy and to reduce the incidence of pregnancy complications, especialy preterm labour and pre labour rupture of membrane. Objectives: Assessment of correlation between maternal serum ZINC level and the prelabour rupture of membrane in both preterm and term pregnant women. Study Design: Case control study. Materials and Methods: A case control study performed in Al-Imamain Al- Kadhumain Medical City/Obstetrics and Gynecology department from 1 st of February to 1 st of November 2019, Including 400 pregnant women their gestational age ranged between (24 to 42) divided in to 4 group: group A, group B, group C, group D which all undergo serum Zinc level measurement. Result: The mean ± SD of serum ZINC in group A which include the preterm prom, which is less than the control group (B) preterm intact membranes which, and the mean ± SD of serum zinc of group (C) which include the term prelabour rupture of membranes which is less than group (D) which is the control group of group (C) term intact membranes. This study shows significant relationship between ZINC deficiency and prelabour rupture of membrane in both term and preterm pregnant women at a P value< 0.001 and <0.001 respectively, also this study show inverse relationship between serum zinc and increasing parity, maternal age, vaginal infection, and BMI. Conclusion: Pregnant women with prelabour rupture of membranes wether term or preterm tend to have lower Zinc level. Increasing maternal age, increasing parity, high BMI, vaginal infection are associated with low Zinc.