Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
NG2‐glia crosstalk with microglia in health and disease
View through CrossRef
AbstractNeurodegenerative diseases are increasingly becoming a global problem. However, the pathological mechanisms underlying neurodegenerative diseases are not fully understood. NG2‐glia abnormalities and microglia activation are involved in the development and/or progression of neurodegenerative disorders, such as multiple sclerosis, Alzheimer's disease, Parkinson's disease, and cerebrovascular diseases. In this review, we summarize the present understanding of the interaction between NG2‐glia and microglia in physiological and pathological states and discuss unsolved questions concerning their fate and potential fate. First, we introduce the NG2‐glia and microglia in health and disease. Second, we formulate the interaction between NG2‐glia and microglia. NG2‐glia proliferation, migration, differentiation, and apoptosis are influenced by factors released from the microglia. On the other hand, NG2‐glia also regulate microglia actions. We conclude that NG2‐glia and microglia are important immunomodulatory cells in the brain. Understanding the interaction between NG2‐glia and microglia will help provide a novel method to modulate myelination and treat neurodegenerative disorders.
Title: NG2‐glia crosstalk with microglia in health and disease
Description:
AbstractNeurodegenerative diseases are increasingly becoming a global problem.
However, the pathological mechanisms underlying neurodegenerative diseases are not fully understood.
NG2‐glia abnormalities and microglia activation are involved in the development and/or progression of neurodegenerative disorders, such as multiple sclerosis, Alzheimer's disease, Parkinson's disease, and cerebrovascular diseases.
In this review, we summarize the present understanding of the interaction between NG2‐glia and microglia in physiological and pathological states and discuss unsolved questions concerning their fate and potential fate.
First, we introduce the NG2‐glia and microglia in health and disease.
Second, we formulate the interaction between NG2‐glia and microglia.
NG2‐glia proliferation, migration, differentiation, and apoptosis are influenced by factors released from the microglia.
On the other hand, NG2‐glia also regulate microglia actions.
We conclude that NG2‐glia and microglia are important immunomodulatory cells in the brain.
Understanding the interaction between NG2‐glia and microglia will help provide a novel method to modulate myelination and treat neurodegenerative disorders.
Related Results
Induction of prostaglandin E2 synthesis and microsomal prostaglandin E synthase–1 expression in murine microglia by glioma-derived soluble factors
Induction of prostaglandin E2 synthesis and microsomal prostaglandin E synthase–1 expression in murine microglia by glioma-derived soluble factors
Object
Microglia are one of the members of monocyte/macrophage lineage in the central nervous system (CNS) and exist as ramified microglia in a normal resting state, but they are a...
pEGFR promotes the neural function recovery after decompression of compressed spinal cord injury
pEGFR promotes the neural function recovery after decompression of compressed spinal cord injury
Abstract
Purpose Investigating the roles of phosphorylated epidermal growth factor receptor (pEGFR) in the recovery of neural function after decompression of CSCI, therefor...
<b>Extracellular cleavage of microglia-derived progranulin promotes diet-induced obesity</b>
<b>Extracellular cleavage of microglia-derived progranulin promotes diet-induced obesity</b>
<p dir="ltr"><b>ABSTRACT</b></p><p dir="ltr">Hypothalamic innate immune responses to dietary fats underpin the pathogenesis of obesity, in which micro...
<b>Extracellular cleavage of microglia-derived progranulin promotes diet-induced obesity</b>
<b>Extracellular cleavage of microglia-derived progranulin promotes diet-induced obesity</b>
<p dir="ltr"><b>ABSTRACT</b></p><p dir="ltr">Hypothalamic innate immune responses to dietary fats underpin the pathogenesis of obesity, in which micro...
Integrating human iPSC-derived macrophage progenitors into retinal organoids to generate a mature retinal microglial niche
Integrating human iPSC-derived macrophage progenitors into retinal organoids to generate a mature retinal microglial niche
AbstractIn the retina, microglia are resident immune cells that are essential for retinal development and function. Retinal microglia play a central role in mediating pathological ...
Neuroinflammation-induced neurodegeneration and associated microglia activation in Parkinson’s disease: a novel neurotherapeutic avenue
Neuroinflammation-induced neurodegeneration and associated microglia activation in Parkinson’s disease: a novel neurotherapeutic avenue
Parkinson’s disease (PD) is classified as one type of neurodegenerative disorder. Movement disorder, which includes resting tremors and slowness of movement, is a common clinical s...
Efficacy of TSPO ligands on neuronal damage mediated by LPS-stimulated BV-2 microglial activation
Efficacy of TSPO ligands on neuronal damage mediated by LPS-stimulated BV-2 microglial activation
Abstract
Background
Neuroinflammation mediated by microglia is an important pathological process of neurodegenerative diseases. Alleviating the inflammatory response cause...
Dark microglia: A new phenotype predominantly associated with pathological states
Dark microglia: A new phenotype predominantly associated with pathological states
The past decade has witnessed a revolution in our understanding of microglia. These immune cells were shown to actively remodel neuronal circuits, leading to propose new pathogenic...