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Environmental covariates: Effects on the power of sib‐pair linkage methods
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AbstractThe effect of inclusion of environmental risk factors on the power of sib‐pair linkage methods was tested for a qualitative trait. It was found that inclusion of an environmental variable did not increase the power of the Haseman‐Elston (H‐E) sib‐pair nonparametric linkage analysis test. However, a significant increase in power was observed for both the H‐E and affected‐sib‐pair tests, even in small samples, when persons unexposed to the environmental risk factor were coded as unknown.
Title: Environmental covariates: Effects on the power of sib‐pair linkage methods
Description:
AbstractThe effect of inclusion of environmental risk factors on the power of sib‐pair linkage methods was tested for a qualitative trait.
It was found that inclusion of an environmental variable did not increase the power of the Haseman‐Elston (H‐E) sib‐pair nonparametric linkage analysis test.
However, a significant increase in power was observed for both the H‐E and affected‐sib‐pair tests, even in small samples, when persons unexposed to the environmental risk factor were coded as unknown.
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