Clinical Manifestations and Prognosis of Unexpected Uterine Sarcoma

Abstract Background To investigate the clinical manifestations and treatment of unexpected uterine sarcoma (UUS) and thus to improve the preoperative diagnostic rate and to reduce the risk of unexpected tumor dissemination. Methods The study retrospectively analyzed 45 UUS patients and 21 patients of preoperatively diagnosed uterine sarcoma (PDUS). We used the χ2 and T tests to assess the incidence and clinical features of patients. The Kaplan-Meier method was used to calculated disease related survival. Results The incidence of UUS is (45/6625) 0.67%.The incidence of UUS in patients undergoing total hysterectomy was higher than that in patients undergoing tumor resection (P < 0.001); The age of UUS is younger than that of PDUS (P = 0.046); The differences in menopausal status and primary complaints between the two groups are not statistically significant (P > 0.05).PDUS group had more patients with Stage II and III sarcomas than that of UUS group(P < 0.001); Duration of symptoms in PDUS group was longer than that of UUS group( P = 0.033). The 5-year overall survival(OS) rate of UUS group(77.7%) is higher than that of PDUS group(46.3% ) (P < 0.001). Conclusions The incidence of UUS is low. UUS has younger age of onset, shorter history of disease, earlier clinical stage, and better prognosis.