Fermented jackfruit leaf beverage offers new affordable and effective diabetes therapy

Diabetes mellitus is complicated multifactorial disorders characterised by hyperglycemia or glucose intolerance. Globally, the number of people suffering from diabetes has increased steadily. Jackfruit leaf, a rich source of phytochemicals offers the opportunity for the development of value-added products. A fermented jackfruit leaf beverage product was developed using symbiotic culture of bacteria and yeast (SCOBY) as cost-effective beneficial treatment for mankind in the management of diabetes. The effectiveness of this fermented jackfruit leaf beverage as an anti-diabetic therapy agent was evaluated using Streptozotocin-induced Sprague Dawley rats model for 4 weeks. The findings depict that, there was a remarkable reduction of blood glucose level in fermented jackfruit leaf-treated diabetic rats as opposed to non-treated diabetic rats, comparable with metformin-treated diabetic rats. The body weight and various relative organ weights of diabetic rats treated with fermented jackfruit leaf beverage showed a healthy recovery sign from diabetes symptoms. The blood haematology profile, liver and kidney function analysis revealed no toxic effect of prolong fermented jackfruit leaf beverage consumption. These results indicated that fermented jackfruit leaf beverage has similar anti-diabetic properties with commercial anti-diabetic drugs with no adverse side effect. Promisingly, it offers a cheaper source to alleviate the diabetes epidemic in a natural way.