Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Approach to the Patient with Hyperhomocysteinemia
View through CrossRef
Hyperhomocysteinaemia (HHC) may occur as a result of a variety of inherited and acquired conditions ranging from mild and benign to severe and life threatening, and there is a higher probability that they will first manifest during early adulthood rather than infancy, with acquired forms commonly presenting into old age. Milder forms of HHC may exist without homocystinuria, and screening tests relying on the presence of homocystine in the urine will give a false negative result. Methylcobalamin is an essential cofactor for methionine synthase, a key enzyme in the homocysteine remethylation pathway: consequently, investigation for inherited abnormalities of intracellular B12 metabolism forms an integral part of the biochemical investigation of HHC. Additionally, there are acquired forms of HHC, notably those involving vitamin B12 deficiency and malabsorption. Mild to moderate HHC has also been associated with alcohol abuse, excessive caffeine intake, hypothyroidism, and poor renal function.
Title: Approach to the Patient with Hyperhomocysteinemia
Description:
Hyperhomocysteinaemia (HHC) may occur as a result of a variety of inherited and acquired conditions ranging from mild and benign to severe and life threatening, and there is a higher probability that they will first manifest during early adulthood rather than infancy, with acquired forms commonly presenting into old age.
Milder forms of HHC may exist without homocystinuria, and screening tests relying on the presence of homocystine in the urine will give a false negative result.
Methylcobalamin is an essential cofactor for methionine synthase, a key enzyme in the homocysteine remethylation pathway: consequently, investigation for inherited abnormalities of intracellular B12 metabolism forms an integral part of the biochemical investigation of HHC.
Additionally, there are acquired forms of HHC, notably those involving vitamin B12 deficiency and malabsorption.
Mild to moderate HHC has also been associated with alcohol abuse, excessive caffeine intake, hypothyroidism, and poor renal function.
Related Results
Discontinuing Mechanical Ventilation
Discontinuing Mechanical Ventilation
Discontinuing Mechanical Ventilation provides clear, step-by step instructions on how to liberate or “wean” the patient from the ventilator. It explains how to determine when the p...
Anesthesia and Co-Existing Disease
Anesthesia and Co-Existing Disease
Anesthesia and Co-existing Diseases provides a timely, rapid overview of common and uncommon co-morbidities that are encountered in the day-to-day practice of anesthesiology. It pr...
Patient Navigation and Cancer Care Delivery
Patient Navigation and Cancer Care Delivery
Although the US health care system offers the very best care to many, the poor and uninsured typically face challenges in accessing timely health care, even when faced with a life-...
Care of the Patient: Art or Science?
Care of the Patient: Art or Science?
The work of the late Dr. George Engel comprises this chapter, which was originally published the same year as Engel’s classic Science article. The “Care of the Patient” piece is bo...
Racconti 33
Racconti 33
Narrative Medicine arises from an attempt to fill the gaps in evidence-based medicine, such as consideration for the care and personal aspects of the patient: humanitarian study in...
Introduction to the surgical patient
Introduction to the surgical patient
The surgical patient undergoes operative procedures to remove or replace diseased organs/tissue. Specific aspects of the surgical patient’s care are different to those of a medical...
Cough and Dyspnea in a Sarcoma Patient
Cough and Dyspnea in a Sarcoma Patient
These case studies illustrate infections encountered in hospitals among patients with compromised immune systems. As a result of immunocompromise, the patients are vulnerable to co...
Pain Management Assessment Beyond the Physician Encounter
Pain Management Assessment Beyond the Physician Encounter
The long-term use of opioids in the treatment of chronic pain patients has increased dramatically over the last two decades. With this increase has come abuse, misuse, diversion, a...