Hepatoprotective Effect of Cinnamon (Cinnamomumzeylanicum) on Paracetamol Induced Liver Damage in Long-Evans Male Rats

Abstract Background: Liver is a vital organ in the body is primarily responsible for the metabolism of endogenous and exogenous agents. It can be damaged by poisonous effects of chemicals, toxins, prolonged and uncontrolled use of drugs. Cinnamon is an evergreen tree. The inner bark of the tree has been used as spice and flavoring for food which may have hepatoprotective effect. Objective: To observe the effect of cinnamon (Cinnamomumzeylanicum) on paracetamol induced liver damage in Long-Evansmale rats. Method: This study was carried out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka from 1st July 2019 to 30th June 2020. A total number of thirty (30) apparently healthy Long-Evansmale rats were taken for the study. They were divided into two groups, control group (Group A) and experimental group (Group B –cinnamon pretreated and paracetamol treated group). Control group was subdivided into group A1 (baseline control) and group A2 (paracetamol treated control group). Each of this group consisted of ten (10) rats. Result: The mean serum total bilirubin, ALT, AST levels were significantly higher in paracetamol treated control group and cinnamon pretreated and paracetamol treated group in comparison to those of baseline control group. Again, the mean serum total bilirubin, ALT, AST levels were significantly lower in cinnamon pretreated and paracetamol treated group in comparison to those ofparacetamol treated control group. Again, the mean malondialdehyde (MDA) concentration in liver was significantly higher in paracetamol treated control group and cinnamon pretreated and paracetamol treated group in comparison to that of baseline control group.Again the mean malondialdehyde (MDA) concentration in liver was significantly lower incinnamon pretreated and paracetamol treated group in comparison to that ofparacetamol treated control group. Moreover, abnormal histological findings of liver were observed in 0% of rats in baseline control group, 100% of rats inparacetamol treated control group, 30% of rats in cinnamon pretreated and paracetamol treated group. Conclusion: The present study reveals that cinnamon has hepatoprotective effect against paracetamol induced liver damage in Long-Evans male.