Laboratory Testing Strategies

Laboratory confirmation of HIV infection is primarily through the detection of HIV antibodies in an individual. Using the current immunoassays and confirmatory testing, false-positive results are exceedingly rare. However, providers should use clinical judgment when interpreting test results and consider additional follow-up testing when appropriate. False-negative immunoassays are also exceedingly rare except for individuals who are early in their infection and have yet to produce HIV antibodies that are detectable by current assays. Rapid HIV tests have similar testing accuracies as compared to those of currently available immunoassays and can be useful testing options for settings such as health fairs, nonclinical locations, and other situations in which quickly receiving preliminary test results would be beneficial.