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Cutaneous Malignant Melanoma Appearing during Photochemotherapy of Mycosis fungoides
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We report a case of malignant melanoma that appeared in a 56-year-old man with mycosis fungoides (stage la) during treatment with PUVA. The cumulative UVA dose was 1 177 J/cm2. The pigmented lesion was removed and PUVA therapy discontinued. Histological examination revealed a superficial spreading malignant melanoma (1.77 mm thick, Clark level IV). The delayed-type cutaneous hypersensitivity was studied. The presence of a second malignancy after mycosis fungoides and PUVA therapy may have been coincidental. Nevertheless, this case suggests that the immunosuppression induced by mycosis fungoides and by PUVA therapy might be a pathogenetic factor in the development of malignant melanoma.
Title: Cutaneous Malignant Melanoma Appearing during Photochemotherapy of Mycosis fungoides
Description:
We report a case of malignant melanoma that appeared in a 56-year-old man with mycosis fungoides (stage la) during treatment with PUVA.
The cumulative UVA dose was 1 177 J/cm2.
The pigmented lesion was removed and PUVA therapy discontinued.
Histological examination revealed a superficial spreading malignant melanoma (1.
77 mm thick, Clark level IV).
The delayed-type cutaneous hypersensitivity was studied.
The presence of a second malignancy after mycosis fungoides and PUVA therapy may have been coincidental.
Nevertheless, this case suggests that the immunosuppression induced by mycosis fungoides and by PUVA therapy might be a pathogenetic factor in the development of malignant melanoma.
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