Formulation and Characterization of transdermal patches loaded with Naringin

A Transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specificdose of medication through the skin and into the blood stream. The transdermal drug deliverysystem is one of novel drug delivery system which overcomes the conventional dosage form andoffers controlled release of the drug into the patient. Naringin has poor bioavailability in the oraldosage form so the transdermal patch of Naringin increases the bioavailability of the drug withrespect to the oral dosage form to reduce the inflammation with minimal drug content complianceto the patient. The aim of the study is to develop a transdermal patch loaded with Naringin for thepurpose of inflammation. The formulation was achieved using Hydroxypropylmethylcellulose(HPMC) and ethylcellulose (EC) as the polymeric release controlling matrix for sustain release ofthe Naringin drug. The formulation development has been carried out through solvent evaporationmethod with an objective to deliver the drug in systemic circulation through skin at predeterminedrate with minimal inter and intrapatient variation. Among the formulations developed(NGP1,NGP2, NGP3, NPG4) formulation NGP4 shows significant results, thus confirms the aim of study.