IMMUNOHISTOCHEMICAL EXPRESSION OF VIMENTIN IN CERVICAL CARCINOMA AND ITS CORRELATION WITH CLINICOPATHOLOGICAL PARAMETERS

Objective: To evaluate the signicance of vimentin expression in cervical carcinoma and correlate it with various prognostic factors like tumor size, tumor type, histological grade, lymph node status and Ki-67 status. The Prospective study was Material and Methods: carried out in the Department of Pathology of SRMS IMS, Bareilly over a period of 1.5 years from March 2021 to August 2022.Fifty histologically conrmed cervical carcinoma cases were included. The expression of vimentin and Ki67 proteins in cervical carcinoma tissues were assessed using immunohistochemical method. Correlations between vimentin expression with clinicopathological features and Ki67 status were analyzed . Results: Among 50 cases studied, maximum number of patients were diagnosed as squamous cell carcinoma(84%) and rest as adenocarcinoma (16%).Vimentin expression was positive in 28.6% cases of squamous cell carcinoma and 37.5% cases of adenocarcinoma. High Ki67 index was seen in 66.6% cases of SCC and 62.5% cases of adenocarcinoma. No signicant correlation was found between vimentin expression and various clinicopathological features like age, tumor size, tumor type, histological grade, lymph node status and clinical stage.However,there was a weak correlation between the expression of vimentin and Ki67status. Our ndings do not s Conclusion: uggest a possible role of Vimentin expression in progression and prognosis of cervical cancer