Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Diagnostic and prognostic value of c-MYC gene expression in hematological malignancies
View through CrossRef
Introduction: c-MYC plays vital role in regulation of cell proliferation and has been associated with tumorigenesis. This studyis aimed at assessing diagnostic and prognostic value of plasma c-MYC expression to aid in early diagnosis and prognosis ofhematological malignancies.
Methods: Plasma c-MYC expression was determined by quantitative real time PCR using EVA Green chemistry and cluster ofdifferentiation markers performed via immunocytochemistry.
Result: Plasma c-MYC was higher in subject with hematological malignancies (8.8 ± 1.1) when compared with apparently healthy controls (4.5 ± 0.5). A screening cut-off c-MYC ratio value of 9.42 with sensitivity and specificity of 65.5% and 100% respectively were obtained using receiver operator characteristic curve analysis. Plasma c-MYC was found to have no prognostic value using Kaplan-Meier analysis.
Conclusion: Plasma c-MYC ratio showed promising screening/diagnostic value for hematological malignancies.
Keywords: c-MYC; c-MYC screening; prognosis with c-MYC; hematological malignancies; plasma c-MYC; c-MYC in malignancies;c-MYC expression.
African Journals Online (AJOL)
Title: Diagnostic and prognostic value of c-MYC gene expression in hematological malignancies
Description:
Introduction: c-MYC plays vital role in regulation of cell proliferation and has been associated with tumorigenesis.
This studyis aimed at assessing diagnostic and prognostic value of plasma c-MYC expression to aid in early diagnosis and prognosis ofhematological malignancies.
Methods: Plasma c-MYC expression was determined by quantitative real time PCR using EVA Green chemistry and cluster ofdifferentiation markers performed via immunocytochemistry.
Result: Plasma c-MYC was higher in subject with hematological malignancies (8.
8 ± 1.
1) when compared with apparently healthy controls (4.
5 ± 0.
5).
A screening cut-off c-MYC ratio value of 9.
42 with sensitivity and specificity of 65.
5% and 100% respectively were obtained using receiver operator characteristic curve analysis.
Plasma c-MYC was found to have no prognostic value using Kaplan-Meier analysis.
Conclusion: Plasma c-MYC ratio showed promising screening/diagnostic value for hematological malignancies.
Keywords: c-MYC; c-MYC screening; prognosis with c-MYC; hematological malignancies; plasma c-MYC; c-MYC in malignancies;c-MYC expression.
Related Results
<i>MYC</i> rearrangement but not extra <i>MYC</i> copies is an independent prognostic factor in patients with mantle cell lymphoma
<i>MYC</i> rearrangement but not extra <i>MYC</i> copies is an independent prognostic factor in patients with mantle cell lymphoma
Mantle cell lymphoma (MCL) with MYC rearrangement (MYC-R) is rare and little is known about the importance of MYC extra copies (EC) in the absence of MYC-R in MCL patients. This st...
Improving immunotherapy in high-grade B-cell lymphoma
Improving immunotherapy in high-grade B-cell lymphoma
MYC is a transcription factor that upon deregulation acts as an oncogene. Cancer patients with MYC overexpression face significant worse outcomes to treatment with (immuno)chemothe...
Abstract 4761: Investigation of the role of N-MYC in lung neuroendocrine carcinoma
Abstract 4761: Investigation of the role of N-MYC in lung neuroendocrine carcinoma
Abstract
Small cell lung cancer and large cell neuroendocrine carcinoma are classified as high-grade neuroendocrine tumors of the lung, representing extremely agg...
Flow Cytometry and Cytogenetics of Fine Needle Aspiration Biopsy Samples Is a Reliable Method for Diagnosing Burkitt Lymphoma. Evaluation of 78 Cases from a Single-Institution
Flow Cytometry and Cytogenetics of Fine Needle Aspiration Biopsy Samples Is a Reliable Method for Diagnosing Burkitt Lymphoma. Evaluation of 78 Cases from a Single-Institution
Abstract
Background: The diagnosis of Burkitt lymphoma (BL) is usually based on histopathology (HP), immunohistochemistry (IHC), fluorescence in situ hybridization (...
Alternating cycles of quiescent and proliferative cell states determine stemness and leukemia-initiation capacity in acute lymphoblastic leukemia
Alternating cycles of quiescent and proliferative cell states determine stemness and leukemia-initiation capacity in acute lymphoblastic leukemia
Abstract
Background and significance. Stemness in acute myeloid leukemia (AML) is determined by a clonal hierarchy with ...
Are Cervical Ribs Indicators of Childhood Cancer? A Narrative Review
Are Cervical Ribs Indicators of Childhood Cancer? A Narrative Review
Abstract
A cervical rib (CR), also known as a supernumerary or extra rib, is an additional rib that forms above the first rib, resulting from the overgrowth of the transverse proce...
Abstract 1872: Targeting MYC-driven medulloblastoma using inhibitors of glutamine metabolism.
Abstract 1872: Targeting MYC-driven medulloblastoma using inhibitors of glutamine metabolism.
Abstract
Medulloblastoma is the most common malignant brain tumor in children. Currently, treatment consists of surgical resection, chemotherapy, and whole brain and...
Abstract 1457: NELFE regulates chromatin accessibility to affect MYC induced transcription
Abstract 1457: NELFE regulates chromatin accessibility to affect MYC induced transcription
Abstract
Liver cancer incidence rates have more than tripled in the last 40 years and is projected to increase more than 40% in the next decade. Although progress ha...