Comparative Study between Preoperative Nebulization with Magnesium Sulfate and Ketamine in the Prevention of Postoperative Sore Throat during General Anesthesia with Endotracheal Intubation in Adults, a Randomized Double Blinded Clinical Trial

Abstract Background Post operative sore throat (POST) is a common complication following general anesthesia requiring endotracheal intubation with incidence ranges from 21% to 65%, also it may consider a minor complication, but if left unresolved, it produces significant agony and annoyance to the patients, if it was severe, it may be associated with hoarseness of voice or change of voice. Aim of the Work In our study we compare between ketamine nebulization and magnesium sulphate nebulization to evaluate their efficacy in decreasing incidence and severity of POST and concluding which drug is better. Patients and Methods This study is a randomized double blinded clinical trial, after obtaining approval from the research ethical committee of Faculty of Medicine, Ain Shams University, this study was conducted in the operating theaters of Ain Shams University Maternity Hospital. Patients were randomly allocated by computer generated randomization into two groups (M, K) each group 20 patients: group Magnesium (M): patients received preoperative nebulization with 250 mg magnesium sulfate in 5ml saline, group Ketamine (K): patients received preoperative nebulization with 50 mg ketamine in 5ml saline. Results The result of the study showed that preoperative nebulization with ketamine 50mg is more effective than preoperative nebulization with magnesium sulfate 250mg in reducing incidence and severity of post operative sore throat especially early after operation. Conclusion We conclude that preoperative nebulization with ketamine 50mg is more effective than preoperative nebulization with magnesium sulfate 250mg in reducing incidence and severity of post operative sore throat especially early after operation.