Abstract LB-173: Disparities in tobacco-related cancer trends

Abstract Tobacco-Related cancers (TRC) pose disproportionate burden of disease among racially ethnic groups. The State of Florida ranks second in the nation for both incidence and mortality from TRC. More than 1 in 3 cancer-related deaths are attributable to tobacco use, either in active or passive form. The decline in tobacco use in the past few decades may have led to a decrease in the overall incidence of TRC. However, the literature suggests that there are important gender and ethno-racial disparities in the observed decreasing trend. The purpose of the study is to characterize these gender and ethno-racial disparities in incidence trends of TRC in Florida. TRC incidence cases were drawn from Florida Cancer Data System (FCDS) and included cancers of the lung and bronchus, oral cavity and pharynx, larynx, esophagus, stomach, pancreas, kidney and renal pelvis, urinary bladder, and cervix, and acute myeloid leukemia. The FCDS is the largest population-based cancer incidence registry in the nation. The diagnosis of TRC had to be the first lifetime cancer diagnosis for the study participants to be included in the study. The primary outcome of interest was the age-adjusted incidence rates. The age-adjusted incidence rates for each of the anatomic sites for the tobacco-related cancers was evaluated using the annual percentage change (APC) to characterize the trends in incidence by gender, race/ethnicity, and stage at diagnosis. A total of 413,090 cases of TRC cancer were identified from 2000- 2012. Study population was older (about 90% were more than 50 years old), had more whites (82%), more males (58%), and included a greater proportion of patients on Medicare (56%). Cancers of the lung and bronchus had the highest frequency distribution (49%). The overall age-adjusted incidence of cancer of the lung and bronchus was significantly decreasing for Non Hispanic Whites while a slight increase was observed for Hispanics. For pancreatic cancer, the incidence was increasing for both Blacks and Hispanics. For kidney cancer, it was increasing for both Blacks and Hispanics. For Bladder cancer, a greater decline was observed among Hispanics than Whites. For cancer of the tonsils, the age- adjusted incidence was significant among the three racial groups with an increase for whites and Hispanics, and a decline among Blacks. Significant decreasing trends were observed for both sexes for lung/bronchus cancer with a greater decline in males. Significant trends were also observed for the pharynx, larynx, and lip cancers for both females and males. With respect to the stage diagnoses, a significant decreasing trend was only observed for lung/bronchus cancer with the regional stage having the largest decline. Analyzing temporal trends in TRC incidence can provide a clearer picture of the cancer burden due to tobacco use and generate insight into the effect of various interventions. Characterizing these gender and ethno-racial disparities has important public health implications, especially for Florida, a state with great racial and ethnic diversity. Citation Format: Rima Tawk, Alice Parish, Yi Guo. Disparities in tobacco-related cancer trends [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr LB-173. doi:10.1158/1538-7445.AM2017-LB-173