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In vitro activity of beauvericin against all developmental stages of Sarcoptes scabiei
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Abstract
Background
Scabies is a frequent cutaneous infection caused by the mite
Sarcoptes scabiei
in a large number of mammals including humans. As the resistance of
S. scabiei
against several chemical acaricides has been previously documented, the establishment of alternative and effective control molecules is required.
Objectives
In this study, the potential acaricidal activity of beauvericin was assessed against different life stages of
S. scabiei
var.
suis
and, in comparison with dimpylate and ivermectin, two commercially available molecules used for the treatment of
S. scabiei
infection in animals and/or humans.
Methods
In our
in vitro
model, developmental stages of
S. scabiei
have been placed in Petri dishes filled with Columbia agar supplemented with pig serum and different concentrations of the drugs. Moreover, the toxicity of beauvericin against cultured human fibroblast skin cells was evaluated using an MTT proliferation assay
Results
Beauvericin showed higher activity against adults and eggs of
S. scabiei
when compared to dimpylate and ivermectin. In addition, cell sensitivity assays demonstrated low toxicity of beauvericin against primary human fibroblast skin cells.
Conclusion
These results revealed that the use of beauvericin is promising and might be considered for the treatment of
S. scabiei
infection.
Title: In vitro
activity of beauvericin against all developmental stages of
Sarcoptes scabiei
Description:
Abstract
Background
Scabies is a frequent cutaneous infection caused by the mite
Sarcoptes scabiei
in a large number of mammals including humans.
As the resistance of
S.
scabiei
against several chemical acaricides has been previously documented, the establishment of alternative and effective control molecules is required.
Objectives
In this study, the potential acaricidal activity of beauvericin was assessed against different life stages of
S.
scabiei
var.
suis
and, in comparison with dimpylate and ivermectin, two commercially available molecules used for the treatment of
S.
scabiei
infection in animals and/or humans.
Methods
In our
in vitro
model, developmental stages of
S.
scabiei
have been placed in Petri dishes filled with Columbia agar supplemented with pig serum and different concentrations of the drugs.
Moreover, the toxicity of beauvericin against cultured human fibroblast skin cells was evaluated using an MTT proliferation assay
Results
Beauvericin showed higher activity against adults and eggs of
S.
scabiei
when compared to dimpylate and ivermectin.
In addition, cell sensitivity assays demonstrated low toxicity of beauvericin against primary human fibroblast skin cells.
Conclusion
These results revealed that the use of beauvericin is promising and might be considered for the treatment of
S.
scabiei
infection.
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