H. pylori were related to osteoporosis but only in female: a cross-sectional study

Abstract Background Recently, more and more studies attach their attention to the extragastrointestinal effects of Helicobacter pylori (H. pylori) . Osteoporosis is an asymptomatic disease which can eventually lead to fractures, have a significant impact on the life quality of the elderly. Sex as an influential factor plays a crucial rule in the development of osteoporosis. The aim of the study is to investigate the relationship between H. pylori and osteoporosis, and find the potential, influential biomarker in different gender, in Chinese population. Method We conducted a cross-sectional study within the study population older than 50 years old, who have had regularly body examination in Beijing shijitan hospital health examination center in 2018 July to October . Participants for the patient profile, serum sample, H. pylori infection status, comorbidity, medicin e use, lumbar dual-energy X-ray absorptiometry were collected. Multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression among the normal, osteopenia, osteoporosis group with the H. pylori infection and the markers . And then we analyzed the correlation between the gender and the potential serum biomarkers. Results There are significant differences between the H. pylori infection statue with the bone density in the female(P=0.044), but not in the male(P=0.381). And in female. , H. pylori (OR=0.200,95%CI 0.043-0.938, P=0.041) is related to osteoporosis, Body Mass Index (BMI) is close to have statistical significance (OR=7.706,95%CI 0.936-63.497, P=0.058). Furthermore, pepsinogen1 (OR=0.246,95%CI 0.091-0.662 P=0.006), Waist-to-Hip Ratio (OR=7.268 OR=2.291-23.196 P=0.001), triglyceride (OR=0.310,95%CI 0.125-0.768,P=0.011),CA724(OR=1.244,95%CI 1.244-8.671 P=0.016),BMI(OR=0.071,95CI% 0.024-0.207 P≤0.001) have a significant difference within different gender, all excluding age as a confounder, all excluding age as a confounder. Conclusion Low BMI, and H. pylori positivity were risk factors for osteoporosis but only for female not for male.