2D Perovskites for Biological Sensors

2D perovskite’s quantum confinement and superlattices enhance electron and hole recombination which maximizes the photoluminescence quantum efficiency for optical devices. However, only a few works have been reported for biological applications, especially, DNA associated. Contemporary gene-editing science through CRISPR technology is advantageous as all types of nucleic acid chains such as RNA, single-stranded DNA, and double-stranded DNA can be modified. There are numerous reports that base pairs of nucleic acids are nonpolar and 2D perovskites that are capped with aliphatic chains possibly can operate as an optical sensor for detecting a specific sequence of DNA. Here, we demonstrate organic-inorganic halide 2D perovskite’s – capped with eight carbon long aliphatic chains – optical and structural properties. Self-assembly of tin-based perovskites showed near-unity photoluminescence quantum yield but had poor stability in water or ambient condition due to hydrolysis whereas lead-based perovskites showed less PL but were stable in water at high concentration. 2D perovskites’ unique multiple emission peaks at different wavelengths, water stability, and intensity discrepancy when conjugated in nucleoside dispersed solution were studied. However, complex multiple directionalities of PL emission, water stability by concentration, minor PL intensity or wavelength discrepancy, and toxicity followed by the lead source for the perovskites are conflicting with robust and convenient detection technique for the DNA.