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Biomarkers in Cancer Epidemiology
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Biomarkers have played an important role in cancer epidemiology since the 1980s. Their integration may be used in several ways, including to measure exposures or exposure dose, to assess intermediate effects of risk factors, to understand biological mechanisms of exposures, and to assess cancer subtypes. This chapter describes some of the key methodologic issues and considerations in the use of biological markers in cancer epidemiology. Specifically, issues related to the characterization and variability of biomarkers are considered. In addition, it evaluates the contribution of biomarkers to identifying exposures as carcinogens. Throughout the chapter, methodologic concepts relevant to biomarker research are illustrated with specific examples.
Title: Biomarkers in Cancer Epidemiology
Description:
Biomarkers have played an important role in cancer epidemiology since the 1980s.
Their integration may be used in several ways, including to measure exposures or exposure dose, to assess intermediate effects of risk factors, to understand biological mechanisms of exposures, and to assess cancer subtypes.
This chapter describes some of the key methodologic issues and considerations in the use of biological markers in cancer epidemiology.
Specifically, issues related to the characterization and variability of biomarkers are considered.
In addition, it evaluates the contribution of biomarkers to identifying exposures as carcinogens.
Throughout the chapter, methodologic concepts relevant to biomarker research are illustrated with specific examples.
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